3-Hydroxyterphenyllin, a natural fungal metabolite, induces apoptosis and S phase arrest in human ovarian carcinoma cells

In the present study, we evaluated 3-Hydroxyter-phenyllin (3-HT) as a potential anticancer agent using the human ovarian cancer cells A2780/CP70 and OVCAR-3, and normal human epithelial ovarian cells IOSE-364 as an in vitro model. 3-HT suppressed proliferation and caused cytotoxicity against A2780/C...

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Veröffentlicht in:	International journal of oncology 2017-04, Vol.50 (4), p.1392-1402
Hauptverfasser:	Wang, Yaomin, Compton, Casey, Rankin, Gary O, Cutler, Stephen J, Rojanasakul, Yon, Tu, Youying, Chen, Yi Charlie
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - therapeutic use Apoptosis Apoptosis - drug effects Aspergillus - chemistry Ataxia Telangiectasia Mutated Proteins - metabolism Cancer therapies Care and treatment Cell culture Cell cycle Cell Cycle Proteins - metabolism Cell growth Cell Line, Transformed Cell Line, Tumor Checkpoint Kinase 2 - metabolism Cytotoxicity Deoxyribonucleic acid Development and progression DNA DNA Damage - drug effects Epithelial Cells Female Genetic aspects Genetic regulation Health aspects Humans Immunoglobulins Kinases Membrane Potential, Mitochondrial - drug effects Metabolites Natural products Ovarian cancer Ovarian Neoplasms - drug therapy Ovary - cytology Poly (ADP-Ribose) Polymerase-1 - metabolism Prostate Proteins Rodents S Phase Cell Cycle Checkpoints - drug effects Signal Transduction Studies Terphenyl Compounds - therapeutic use Tumor necrosis factor-TNF Tumor Suppressor Protein p53 - metabolism
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