Early Detection of Acute Drug-Induced Liver Injury in Mice by Noninvasive Near-Infrared Fluorescence Imaging

Hepatocellular and cholestatic forms of drug-induced liver injury (DILI) are major reasons for late-stage termination of small-molecule drug discovery research projects. Biochemical serum markers are limited in their ability to sensitively and specifically detect both of these common DILI forms in p...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2017-04, Vol.361 (1), p.87-98
Hauptverfasser:	Vasquez, Kristine O., Peterson, Jeffrey D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetaminophen - toxicity Animals Chemical and Drug Induced Liver Injury - diagnostic imaging Chemical and Drug Induced Liver Injury - metabolism Early Diagnosis Fluorescent Dyes - administration & dosage Fluorescent Dyes - metabolism Male Mice Mice, Inbred BALB C Mice, Inbred C57BL Optical Imaging - methods Thioacetamide - toxicity Toxicology
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