Stable shRNA Silencing of Lactate Dehydrogenase A (LDHA) in Human MDA-MB-231 Breast Cancer Cells Fails to Alter Lactic Acid Production, Glycolytic Activity, ATP or Survival

In the US, African Americans have a high death rate from triple-negative breast cancer (TNBC), characterized by lack of hormone receptors (ER, PR, HER2/ERRB2) which are otherwise valuable targets of chemotherapy. There is a need to identify novel targets that negatively impact TNBC tumorigenesis. TN...

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Veröffentlicht in:	Anticancer research 2017-03, Vol.37 (3), p.1205-1212
Hauptverfasser:	Mack, Nzinga, Mazzio, Elizabeth A, Bauer, David, Flores-Rozas, Hernan, Soliman, Karam F A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - metabolism Breast Neoplasms - enzymology Breast Neoplasms - genetics Cell Line, Tumor Cell Survival Down-Regulation Female Gene Expression Regulation, Neoplastic Gene Silencing Glucose - metabolism Glycolysis Humans Isoenzymes - genetics Isoenzymes - metabolism L-Lactate Dehydrogenase - genetics L-Lactate Dehydrogenase - metabolism Lactic Acid - metabolism Polymerase Chain Reaction RNA, Small Interfering - genetics
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