Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease

Previously, we reported that Alzheimer’s disease (AD) epitope vaccines (EVs) composed of N-terminal β-amyloid (Aβ42) B cell epitope fused with universal foreign T helper (Th) epitope(s) were immunogenic, potent, and safe in different amyloid precursor protein (APP) transgenic mice with early AD-like...

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Veröffentlicht in:	Molecular therapy 2017-01, Vol.25 (1), p.153-164
Hauptverfasser:	Petrushina, Irina, Davtyan, Hayk, Hovakimyan, Armine, Davtyan, Arpine, Passos, Giselle F., Cribbs, David H., Ghochikyan, Anahit, Agadjanyan, Michael G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - immunology Alzheimer Disease - prevention & control Alzheimer Disease - therapy Alzheimer's disease Amyloid beta-Peptides - immunology Amyloid precursor protein amyloid-β Animal models Animals Antibodies Antibodies - immunology Astrocytes - immunology Astrocytes - metabolism Autoantigens Aβ-pathology Brain - immunology Brain - metabolism Brain - pathology Cortex Disease Models, Animal epitope vaccine Epitopes Epitopes - immunology Helper cells immune responses Immunization Immunogenicity Immunotherapy inflammation Lymphocytes B Lymphocytes T Memory cells Mice Mice, Transgenic microhemorrhages Neuroglia - immunology Neuroglia - metabolism novel object recognition Original Pathology Pattern recognition Peptide Fragments - immunology Plaques preventive and therapeutic vaccines T-Lymphocytes, Helper-Inducer - immunology T-Lymphocytes, Helper-Inducer - metabolism Transgenic mice Vaccines Vaccines - administration & dosage Vaccines - immunology β-Amyloid
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