The Efficacy of Cardiac Anti-miR-208a Therapy Is Stress Dependent

MicroRNAs (miRNAs) are important regulators of biology and disease. Recent animal efficacy studies validate the therapeutic benefit of miRNA modulation and underscore the therapeutic value of miRNA-targeting oligonucleotides. However, whether disease conditions (stress) influence the pharmacological...

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Veröffentlicht in:	Molecular therapy 2017-03, Vol.25 (3), p.694-704
Hauptverfasser:	Eding, Joep E.C., Demkes, Charlotte J., Lynch, Joshua M., Seto, Anita G., Montgomery, Rusty L., Semus, Hillary M., Jackson, Aimee L., Isabelle, Marc, Chimenti, Stefano, van Rooij, Eva
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antagomirs - genetics anti-miR Binding sites Cardiomyocytes Cells, Cultured Derepression Experiments Gene expression Gene Expression Profiling Gene Expression Regulation Hypertension Male microRNA MicroRNAs - genetics miRNA Myocytes, Cardiac - metabolism Oligonucleotides Original Rats RNA Interference Stress, Physiological - genetics Surgery Swine target
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