In vitro reconstitution demonstrates the cell wall ligase activity of LCP proteins

Reconstitution experiments using substrates prepared by chemoenzymatic synthesis demonstrate that three LCP family proteins catalyze the ligation of wall teichoic acids to peptidoglycan in the biosynthesis of the Staphylococcus aureus cell wall. Sacculus is a peptidoglycan (PG) matrix that protects...

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Veröffentlicht in:	Nature chemical biology 2017-04, Vol.13 (4), p.396-401
Hauptverfasser:	Schaefer, Kaitlin, Matano, Leigh M, Qiao, Yuan, Kahne, Daniel, Walker, Suzanne
Format:	Artikel
Sprache:	eng
Schlagworte:	631/92/173 631/92/221 631/92/60 631/92/96 Bacteria Bacterial Proteins - metabolism Biochemical Engineering Biochemistry Bioorganic Chemistry Cell Biology Cell Wall - enzymology Cell Wall - metabolism Cells Chemistry Chemistry/Food Science In Vitro Techniques Ligases - metabolism Molecular Structure Peptidoglycan - chemistry Peptidoglycan - metabolism Proteins Staphylococcus aureus Staphylococcus aureus - cytology Staphylococcus aureus - enzymology Staphylococcus aureus - metabolism
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