An epigenetic modifier induces production of (10′S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla

[Display omitted] Incorporation of the histone deacetylase (HDAC) inhibitor, suberoylanilide hydroxamic acid (SAHA), to a culture broth of the endophytic fungus Phoma sp. nov. LG0217 isolated from Parkinsonia microphylla changed its metabolite profile and resulted in the production of (10′S)-verrucu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry 2017-03, Vol.25 (6), p.1860-1866
Hauptverfasser:	Gubiani, Juliana R., Wijeratne, E.M. Kithsiri, Shi, Taoda, Araujo, Angela R., Arnold, A. Elizabeth, Chapman, Eli, Gunatilaka, A.A. Leslie
Format:	Artikel
Sprache:	eng
Schlagworte:	(10′S)-verruculide B Ascomycota - drug effects Ascomycota - metabolism Chromatography, High Pressure Liquid Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Epigenesis, Genetic - drug effects Epigenetic Fabaceae - microbiology Histone deacetylase inhibitor Magnetic Resonance Spectroscopy Phoma sp. nov. LG0217 Protein tyrosine phosphatases Protein Tyrosine Phosphatases - antagonists & inhibitors Sesquiterpenes - chemistry Sesquiterpenes - metabolism Sesquiterpenes - pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!