Mechanotransduction in cancer

•Tumor tissues stiffen in disease, but cancer cells can soften.•Some cancer cell types lose aspects of stiffness sensing.•Ras, FAK and PI3K/Akt signaling have been implicated in mechanotransduction.•New materials and devices reveal mechanisms of mechanotransduction in cancer. Tissue stiffness is tig...

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Veröffentlicht in:	Current opinion in chemical engineering 2016-02, Vol.11, p.77-84
Hauptverfasser:	Chin, LiKang, Xia, Yuntao, Discher, Dennis E, Janmey, Paul A
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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