Caenorhabditis elegans RIG-I Homolog Mediates Antiviral RNA Interference Downstream of Dicer-Dependent Biogenesis of Viral Small Interfering RNAs

Dicer enzymes process virus-specific double-stranded RNA (dsRNA) into small interfering RNAs (siRNAs) to initiate specific antiviral defense by related RNA interference (RNAi) pathways in plants, insects, nematodes, and mammals. Antiviral RNAi in requires Dicer-related helicase 1 (DRH-1), not found...

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Veröffentlicht in:	mBio 2017-03, Vol.8 (2)
Hauptverfasser:	Coffman, Stephanie R, Lu, Jinfeng, Guo, Xunyang, Zhong, Jing, Jiang, Hongshan, Broitman-Maduro, Gina, Li, Wan-Xiang, Lu, Rui, Maduro, Morris, Ding, Shou-Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caenorhabditis elegans - genetics Caenorhabditis elegans - immunology Caenorhabditis elegans Proteins - metabolism DEAD-box RNA Helicases - metabolism Genetic Testing RNA Interference RNA Viruses - immunology RNA, Small Interfering - metabolism
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