Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy
Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan Trypanosoma cruzi ; it is estimated that 10–30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ven...
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| Veröffentlicht in: | Scientific reports 2017-03, Vol.7 (1), p.44978-44978, Article 44978 |
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| creator | Teixeira, Samuel Cota Lopes, Daiana Silva Gimenes, Sarah Natalie Cirilo Teixeira, Thaise Lara da Silva, Marcelo Santos Brígido, Rebecca Tavares e Silva da Luz, Felipe Andrés Cordero da Silva, Aline Alves Silva, Makswell Almeida Florentino, Pilar Veras Tavares, Paula Cristina Brígido dos Santos, Marlus Alves Ávila, Veridiana de Melo Rodrigues Silva, Marcelo José Barbosa Elias, Maria Carolina Mortara, Renato Arruda da Silva, Claudio Vieira |
| description | Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan
Trypanosoma cruzi
; it is estimated that 10–30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, heart blocks, thromboembolic events and sudden death. Therefore, in this study, we proposed to evaluate the anti-angiogenic activity of a recombinant protein from
T. cruzi
named P21 (rP21) and the potential impact of the native protein on CCC. Our data suggest that the anti-angiogenic activity of rP21 depends on the protein’s direct interaction with the CXCR4 receptor. This capacity is likely related to the modulation of the expression of actin and angiogenesis-associated genes. Thus, our results indicate that
T. cruzi
P21 is an attractive target for the development of innovative therapeutic agents against CCC. |
| doi_str_mv | 10.1038/srep44978 |
| format | Article |
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Trypanosoma cruzi
; it is estimated that 10–30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, heart blocks, thromboembolic events and sudden death. Therefore, in this study, we proposed to evaluate the anti-angiogenic activity of a recombinant protein from
T. cruzi
named P21 (rP21) and the potential impact of the native protein on CCC. Our data suggest that the anti-angiogenic activity of rP21 depends on the protein’s direct interaction with the CXCR4 receptor. This capacity is likely related to the modulation of the expression of actin and angiogenesis-associated genes. Thus, our results indicate that
T. cruzi
P21 is an attractive target for the development of innovative therapeutic agents against CCC.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/srep44978</identifier><identifier>PMID: 28322302</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>13 ; 13/1 ; 13/31 ; 14/63 ; 38 ; 38/39 ; 631/326/88 ; 631/80/83 ; 692/420/254 ; 82 ; 82/16 ; 82/29 ; 82/80 ; 82/83 ; Actin ; Actins - metabolism ; Angiogenesis ; Angiogenesis Inhibitors - metabolism ; Angiogenesis Inhibitors - pharmacology ; Animals ; Cardiomyopathy ; Cell Line ; Cell Proliferation ; Chagas disease ; Chagas Disease - etiology ; Chagas Disease - metabolism ; Chagas Disease - parasitology ; CXCR4 protein ; Cyclin-dependent kinase inhibitor p21 ; Cytoskeleton - metabolism ; Endothelial Cells - drug effects ; Endothelial Cells - metabolism ; Extracellular Matrix ; Gene Expression Regulation ; GTP-binding protein ; Heart diseases ; Humanities and Social Sciences ; Humans ; Medical innovations ; Mice ; Models, Biological ; multidisciplinary ; Neovascularization, Pathologic - genetics ; Neovascularization, Pathologic - metabolism ; Protein Multimerization ; Proteins ; Protozoa ; Protozoan Proteins - metabolism ; Protozoan Proteins - pharmacology ; Receptors, CXCR4 ; Recombinant Proteins - metabolism ; Recombinant Proteins - pharmacology ; Science ; Thromboembolism ; Trypanosoma cruzi - metabolism ; Vector-borne diseases ; Ventricle</subject><ispartof>Scientific reports, 2017-03, Vol.7 (1), p.44978-44978, Article 44978</ispartof><rights>The Author(s) 2017</rights><rights>Copyright Nature Publishing Group Mar 2017</rights><rights>Copyright © 2017, The Author(s) 2017 The Author(s)</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-9214617722c86e20d9ae26aa6e44d757f8d057da87bea0dcda3968b0562a61f53</citedby><cites>FETCH-LOGICAL-c438t-9214617722c86e20d9ae26aa6e44d757f8d057da87bea0dcda3968b0562a61f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359584/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359584/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,42165,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28322302$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teixeira, Samuel Cota</creatorcontrib><creatorcontrib>Lopes, Daiana Silva</creatorcontrib><creatorcontrib>Gimenes, Sarah Natalie Cirilo</creatorcontrib><creatorcontrib>Teixeira, Thaise Lara</creatorcontrib><creatorcontrib>da Silva, Marcelo Santos</creatorcontrib><creatorcontrib>Brígido, Rebecca Tavares e Silva</creatorcontrib><creatorcontrib>da Luz, Felipe Andrés Cordero</creatorcontrib><creatorcontrib>da Silva, Aline Alves</creatorcontrib><creatorcontrib>Silva, Makswell Almeida</creatorcontrib><creatorcontrib>Florentino, Pilar Veras</creatorcontrib><creatorcontrib>Tavares, Paula Cristina Brígido</creatorcontrib><creatorcontrib>dos Santos, Marlus Alves</creatorcontrib><creatorcontrib>Ávila, Veridiana de Melo Rodrigues</creatorcontrib><creatorcontrib>Silva, Marcelo José Barbosa</creatorcontrib><creatorcontrib>Elias, Maria Carolina</creatorcontrib><creatorcontrib>Mortara, Renato Arruda</creatorcontrib><creatorcontrib>da Silva, Claudio Vieira</creatorcontrib><title>Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan
Trypanosoma cruzi
; it is estimated that 10–30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, heart blocks, thromboembolic events and sudden death. Therefore, in this study, we proposed to evaluate the anti-angiogenic activity of a recombinant protein from
T. cruzi
named P21 (rP21) and the potential impact of the native protein on CCC. Our data suggest that the anti-angiogenic activity of rP21 depends on the protein’s direct interaction with the CXCR4 receptor. This capacity is likely related to the modulation of the expression of actin and angiogenesis-associated genes. Thus, our results indicate that
T. cruzi
P21 is an attractive target for the development of innovative therapeutic agents against CCC.</description><subject>13</subject><subject>13/1</subject><subject>13/31</subject><subject>14/63</subject><subject>38</subject><subject>38/39</subject><subject>631/326/88</subject><subject>631/80/83</subject><subject>692/420/254</subject><subject>82</subject><subject>82/16</subject><subject>82/29</subject><subject>82/80</subject><subject>82/83</subject><subject>Actin</subject><subject>Actins - metabolism</subject><subject>Angiogenesis</subject><subject>Angiogenesis Inhibitors - metabolism</subject><subject>Angiogenesis Inhibitors - pharmacology</subject><subject>Animals</subject><subject>Cardiomyopathy</subject><subject>Cell Line</subject><subject>Cell Proliferation</subject><subject>Chagas disease</subject><subject>Chagas Disease - etiology</subject><subject>Chagas Disease - metabolism</subject><subject>Chagas Disease - parasitology</subject><subject>CXCR4 protein</subject><subject>Cyclin-dependent kinase inhibitor p21</subject><subject>Cytoskeleton - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teixeira, Samuel Cota</au><au>Lopes, Daiana Silva</au><au>Gimenes, Sarah Natalie Cirilo</au><au>Teixeira, Thaise Lara</au><au>da Silva, Marcelo Santos</au><au>Brígido, Rebecca Tavares e Silva</au><au>da Luz, Felipe Andrés Cordero</au><au>da Silva, Aline Alves</au><au>Silva, Makswell Almeida</au><au>Florentino, Pilar Veras</au><au>Tavares, Paula Cristina Brígido</au><au>dos Santos, Marlus Alves</au><au>Ávila, Veridiana de Melo Rodrigues</au><au>Silva, Marcelo José Barbosa</au><au>Elias, Maria Carolina</au><au>Mortara, Renato Arruda</au><au>da Silva, Claudio Vieira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2017-03-21</date><risdate>2017</risdate><volume>7</volume><issue>1</issue><spage>44978</spage><epage>44978</epage><pages>44978-44978</pages><artnum>44978</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Chronic chagasic cardiomyopathy (CCC) is arguably the most important form of the Chagas Disease, caused by the intracellular protozoan
Trypanosoma cruzi
; it is estimated that 10–30% of chronic patients develop this clinical manifestation. The most common and severe form of CCC can be related to ventricular abnormalities, such as heart failure, arrhythmias, heart blocks, thromboembolic events and sudden death. Therefore, in this study, we proposed to evaluate the anti-angiogenic activity of a recombinant protein from
T. cruzi
named P21 (rP21) and the potential impact of the native protein on CCC. Our data suggest that the anti-angiogenic activity of rP21 depends on the protein’s direct interaction with the CXCR4 receptor. This capacity is likely related to the modulation of the expression of actin and angiogenesis-associated genes. Thus, our results indicate that
T. cruzi
P21 is an attractive target for the development of innovative therapeutic agents against CCC.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>28322302</pmid><doi>10.1038/srep44978</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | Scientific reports, 2017-03, Vol.7 (1), p.44978-44978, Article 44978 |
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| source | MEDLINE; Nature Free; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry; Springer Nature OA Free Journals |
| subjects | 13 13/1 13/31 14/63 38 38/39 631/326/88 631/80/83 692/420/254 82 82/16 82/29 82/80 82/83 Actin Actins - metabolism Angiogenesis Angiogenesis Inhibitors - metabolism Angiogenesis Inhibitors - pharmacology Animals Cardiomyopathy Cell Line Cell Proliferation Chagas disease Chagas Disease - etiology Chagas Disease - metabolism Chagas Disease - parasitology CXCR4 protein Cyclin-dependent kinase inhibitor p21 Cytoskeleton - metabolism Endothelial Cells - drug effects Endothelial Cells - metabolism Extracellular Matrix Gene Expression Regulation GTP-binding protein Heart diseases Humanities and Social Sciences Humans Medical innovations Mice Models, Biological multidisciplinary Neovascularization, Pathologic - genetics Neovascularization, Pathologic - metabolism Protein Multimerization Proteins Protozoa Protozoan Proteins - metabolism Protozoan Proteins - pharmacology Receptors, CXCR4 Recombinant Proteins - metabolism Recombinant Proteins - pharmacology Science Thromboembolism Trypanosoma cruzi - metabolism Vector-borne diseases Ventricle |
| title | Mechanistic Insights into the Anti-angiogenic Activity of Trypanosoma cruzi Protein 21 and its Potential Impact on the Onset of Chagasic Cardiomyopathy |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T04%3A51%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mechanistic%20Insights%20into%20the%20Anti-angiogenic%20Activity%20of%20Trypanosoma%20cruzi%20Protein%2021%20and%20its%20Potential%20Impact%20on%20the%20Onset%20of%20Chagasic%20Cardiomyopathy&rft.jtitle=Scientific%20reports&rft.au=Teixeira,%20Samuel%20Cota&rft.date=2017-03-21&rft.volume=7&rft.issue=1&rft.spage=44978&rft.epage=44978&rft.pages=44978-44978&rft.artnum=44978&rft.issn=2045-2322&rft.eissn=2045-2322&rft_id=info:doi/10.1038/srep44978&rft_dat=%3Cproquest_pubme%3E1879664122%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1903385232&rft_id=info:pmid/28322302&rfr_iscdi=true |