Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking
A large body of literature supports cognitive enhancement as an effect of cholinergic potentiation. However, it remains elusive whether pharmacological manipulations of cholinergic neurotransmission enhance complex visual processing in healthy individuals. To test this hypothesis, we randomly admini...
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| Veröffentlicht in: | Frontiers in human neuroscience 2017-03, Vol.11, p.128-128 |
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| creator | Chamoun, Mira Huppé-Gourgues, Frédéric Legault, Isabelle Rosa-Neto, Pedro Dumbrava, Daniela Faubert, Jocelyn Vaucher, Elvire |
| description | A large body of literature supports cognitive enhancement as an effect of cholinergic potentiation. However, it remains elusive whether pharmacological manipulations of cholinergic neurotransmission enhance complex visual processing in healthy individuals. To test this hypothesis, we randomly administered either the cholinergic transmission enhancer donepezil (DPZ; 5 mg P.O.) or placebo (lactose) to young adults (
= 17) 3 h before each session of the three-dimensional (3D) multiple object tracking (3D-MOT) task. This multi-focal attention task evaluates perceptual-cognitive learning over five sessions conducted 7 days apart. A significant amount of learning was observed in the DPZ group but not the placebo group in the fourth session. In the fifth session, this learning effect was observed in both groups. Furthermore, preliminary results for a subgroup of participants (
= 9) 4-14 months later suggested the cholinergic enhancement effect was long lasting. On the other hand, DPZ had no effect on basic visual processing as measured by a motion and orientation discrimination task performed as an independent one-time, pre-post drug study without placebo control (
= 10). The results support the construct that cholinergic enhancement facilitates the encoding of a highly demanding perceptual-cognitive task although there were no significant drug effects on the performance levels compared to placebo. |
| doi_str_mv | 10.3389/fnhum.2017.00128 |
| format | Article |
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= 17) 3 h before each session of the three-dimensional (3D) multiple object tracking (3D-MOT) task. This multi-focal attention task evaluates perceptual-cognitive learning over five sessions conducted 7 days apart. A significant amount of learning was observed in the DPZ group but not the placebo group in the fourth session. In the fifth session, this learning effect was observed in both groups. Furthermore, preliminary results for a subgroup of participants (
= 9) 4-14 months later suggested the cholinergic enhancement effect was long lasting. On the other hand, DPZ had no effect on basic visual processing as measured by a motion and orientation discrimination task performed as an independent one-time, pre-post drug study without placebo control (
= 10). The results support the construct that cholinergic enhancement facilitates the encoding of a highly demanding perceptual-cognitive task although there were no significant drug effects on the performance levels compared to placebo.</description><identifier>ISSN: 1662-5161</identifier><identifier>EISSN: 1662-5161</identifier><identifier>DOI: 10.3389/fnhum.2017.00128</identifier><identifier>PMID: 28377707</identifier><language>eng</language><publisher>Switzerland: Frontiers Research Foundation</publisher><subject>Aging ; Attention task ; Cholinergic transmission ; Cognition & reasoning ; Cognitive ability ; Disease ; Donepezil ; Efficiency ; Experiments ; Information processing ; Lactose ; Memory ; Neuroscience ; Neurotransmission ; Noise ; Observational learning ; Orientation behavior ; Potentiation ; Studies ; Visual discrimination ; Young adults</subject><ispartof>Frontiers in human neuroscience, 2017-03, Vol.11, p.128-128</ispartof><rights>2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 Chamoun, Huppé-Gourgues, Legault, Rosa-Neto, Dumbrava, Faubert and Vaucher. 2017 Chamoun, Huppé-Gourgues, Legault, Rosa-Neto, Dumbrava, Faubert and Vaucher</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-e52aa1425531b29703921e01a4213752994e5a81c8ceff692cf94a12a8f4f6bb3</citedby><cites>FETCH-LOGICAL-c424t-e52aa1425531b29703921e01a4213752994e5a81c8ceff692cf94a12a8f4f6bb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359296/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5359296/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28377707$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chamoun, Mira</creatorcontrib><creatorcontrib>Huppé-Gourgues, Frédéric</creatorcontrib><creatorcontrib>Legault, Isabelle</creatorcontrib><creatorcontrib>Rosa-Neto, Pedro</creatorcontrib><creatorcontrib>Dumbrava, Daniela</creatorcontrib><creatorcontrib>Faubert, Jocelyn</creatorcontrib><creatorcontrib>Vaucher, Elvire</creatorcontrib><title>Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking</title><title>Frontiers in human neuroscience</title><addtitle>Front Hum Neurosci</addtitle><description>A large body of literature supports cognitive enhancement as an effect of cholinergic potentiation. However, it remains elusive whether pharmacological manipulations of cholinergic neurotransmission enhance complex visual processing in healthy individuals. To test this hypothesis, we randomly administered either the cholinergic transmission enhancer donepezil (DPZ; 5 mg P.O.) or placebo (lactose) to young adults (
= 17) 3 h before each session of the three-dimensional (3D) multiple object tracking (3D-MOT) task. This multi-focal attention task evaluates perceptual-cognitive learning over five sessions conducted 7 days apart. A significant amount of learning was observed in the DPZ group but not the placebo group in the fourth session. In the fifth session, this learning effect was observed in both groups. Furthermore, preliminary results for a subgroup of participants (
= 9) 4-14 months later suggested the cholinergic enhancement effect was long lasting. On the other hand, DPZ had no effect on basic visual processing as measured by a motion and orientation discrimination task performed as an independent one-time, pre-post drug study without placebo control (
= 10). The results support the construct that cholinergic enhancement facilitates the encoding of a highly demanding perceptual-cognitive task although there were no significant drug effects on the performance levels compared to placebo.</description><subject>Aging</subject><subject>Attention task</subject><subject>Cholinergic transmission</subject><subject>Cognition & reasoning</subject><subject>Cognitive ability</subject><subject>Disease</subject><subject>Donepezil</subject><subject>Efficiency</subject><subject>Experiments</subject><subject>Information processing</subject><subject>Lactose</subject><subject>Memory</subject><subject>Neuroscience</subject><subject>Neurotransmission</subject><subject>Noise</subject><subject>Observational learning</subject><subject>Orientation behavior</subject><subject>Potentiation</subject><subject>Studies</subject><subject>Visual discrimination</subject><subject>Young adults</subject><issn>1662-5161</issn><issn>1662-5161</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNpdkU1v1DAQhiMEoqVw54QsceGSxR-xE1-Qqi3QSkXtYTlwshx3svHi2MF2VuoP4H_jbUtVONnyvPNoxk9VvSV4xVgnPw5-XKYVxaRdYUxo96w6JkLQmhNBnj-5H1WvUtphLKjg5GV1RDvWti1uj6vf6zE46yFurUHXIYPPVmcbPLqY5hj2kNA1RANzXrSr12HrbbZ7QJuorbd-i8KAzkG7PN6iH2EpD6c3i8sJWY82YwRAZ3YCnwpRO_StlOzsAF31OzD5QDE_C-V19WLQLsGbh_Ok-v7l82Z9Xl9efb1Yn17WpqFNroFTrUlDOWekp7LFTFICmOiGEtZyKmUDXHfEdAaGQUhqBtloQnU3NIPoe3ZSfbrnzks_wY0p20bt1BztpOOtCtqqfyvejmob9oozLqkUBfDhARDDrwVSVpNNBpzTHsKSFOm6phEMc1yi7_-L7sISyy8kRWknhZSYkJLC9ykTQ0oRhsdhCFYHx-rOsTo4VneOS8u7p0s8NvyVyv4AzZ6l-g</recordid><startdate>20170321</startdate><enddate>20170321</enddate><creator>Chamoun, Mira</creator><creator>Huppé-Gourgues, Frédéric</creator><creator>Legault, Isabelle</creator><creator>Rosa-Neto, Pedro</creator><creator>Dumbrava, Daniela</creator><creator>Faubert, Jocelyn</creator><creator>Vaucher, Elvire</creator><general>Frontiers Research Foundation</general><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170321</creationdate><title>Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking</title><author>Chamoun, Mira ; 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= 17) 3 h before each session of the three-dimensional (3D) multiple object tracking (3D-MOT) task. This multi-focal attention task evaluates perceptual-cognitive learning over five sessions conducted 7 days apart. A significant amount of learning was observed in the DPZ group but not the placebo group in the fourth session. In the fifth session, this learning effect was observed in both groups. Furthermore, preliminary results for a subgroup of participants (
= 9) 4-14 months later suggested the cholinergic enhancement effect was long lasting. On the other hand, DPZ had no effect on basic visual processing as measured by a motion and orientation discrimination task performed as an independent one-time, pre-post drug study without placebo control (
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| subjects | Aging Attention task Cholinergic transmission Cognition & reasoning Cognitive ability Disease Donepezil Efficiency Experiments Information processing Lactose Memory Neuroscience Neurotransmission Noise Observational learning Orientation behavior Potentiation Studies Visual discrimination Young adults |
| title | Cholinergic Potentiation Improves Perceptual-Cognitive Training of Healthy Young Adults in Three Dimensional Multiple Object Tracking |
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