VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

The ECS (Elongin B/C-Cul2/Cul5-SOCS-box protein) complex is a member of a family of ubiquitin ligases that share a Cullin-Rbx module. SOCS-box proteins recruit substrates to the ECS complex and are linked to Cullin-Rbx via Elongin B/C. VHL has been implicated as a SOCS-box protein, but lacks a C-ter...

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Veröffentlicht in:	Genes & development 2004-12, Vol.18 (24), p.3055-3065
Hauptverfasser:	Kamura, Takumi, Maenaka, Katsumi, Kotoshiba, Shuhei, Matsumoto, Masaki, Kohda, Daisuke, Conaway, Ronald C, Conaway, Joan Weliky, Nakayama, Keiichi I
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Carrier Proteins - metabolism Cell Cycle Proteins - metabolism Cells, Cultured Cullin Proteins - genetics Cullin Proteins - metabolism Gene Components Humans Immunoblotting Immunoprecipitation Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mass Spectrometry Models, Chemical Molecular Sequence Data Protein Binding Protein Structure, Tertiary Proteins - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Research Papers RNA Interference Sequence Alignment Suppressor of Cytokine Signaling 1 Protein Suppressor of Cytokine Signaling Proteins Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Von Hippel-Lindau Tumor Suppressor Protein
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