Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats
Abstract Binge drinking and the onset of alcohol-use disorders usually peak during the transition between late adolescence and early adulthood, and early adolescent onset of alcohol consumption has been demonstrated to increase the risk for alcohol dependence in adulthood. In the present study, we d...
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description | Abstract Binge drinking and the onset of alcohol-use disorders usually peak during the transition between late adolescence and early adulthood, and early adolescent onset of alcohol consumption has been demonstrated to increase the risk for alcohol dependence in adulthood. In the present study, we describe an animal model of early adolescent alcohol consumption where animals drink unsweetened and unflavored ethanol in high concentrations (20%). Using this model, we investigated the influence of drinking on alcohol-related appetitive behavior and alcohol consumption levels in early adulthood. Further, we also sought to investigate whether differences in alcohol-related drinking behaviors were specific to exposure in adolescence versus exposure in adulthood. Male Wistar rats were given a 2-bottle choice between 20% ethanol and water in one group and between two water bottles in another group during their adolescence (Postnatal Day [PD] 26–59) to model voluntary drinking in adolescent humans. As young adults (PD85), rats were trained in a paradigm that provided free access to 20% alcohol for 25 min after completing up to a fixed-ratio (FR) 16 lever press response. A set of young adult male Wistar rats was exposed to the same paradigm using the same time course, beginning at PD92. The results indicate that adolescent exposure to alcohol increased consumption of alcohol in adulthood. Furthermore, when investigating differences between adolescent high and low drinkers in adulthood, high consumers continued to drink more alcohol, had fewer FR failures, and faster completion of FR schedules in adulthood, whereas the low consumers were no different from controls. Rats exposed to ethanol in young adulthood also increased future intake, but there were no differences in any other components of drinking behavior. Both adolescent- and adult-exposed rats did not exhibit an increase in lever pressing during the appetitive challenge session. These data indicate that adolescent and early adult alcohol exposure can increase consumptive aspects of drinking but that adolescent exposure may preferentially influence the motivation to drink. |
doi_str_mv | 10.1016/j.alcohol.2016.12.002 |
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In the present study, we describe an animal model of early adolescent alcohol consumption where animals drink unsweetened and unflavored ethanol in high concentrations (20%). Using this model, we investigated the influence of drinking on alcohol-related appetitive behavior and alcohol consumption levels in early adulthood. Further, we also sought to investigate whether differences in alcohol-related drinking behaviors were specific to exposure in adolescence versus exposure in adulthood. Male Wistar rats were given a 2-bottle choice between 20% ethanol and water in one group and between two water bottles in another group during their adolescence (Postnatal Day [PD] 26–59) to model voluntary drinking in adolescent humans. As young adults (PD85), rats were trained in a paradigm that provided free access to 20% alcohol for 25 min after completing up to a fixed-ratio (FR) 16 lever press response. A set of young adult male Wistar rats was exposed to the same paradigm using the same time course, beginning at PD92. The results indicate that adolescent exposure to alcohol increased consumption of alcohol in adulthood. Furthermore, when investigating differences between adolescent high and low drinkers in adulthood, high consumers continued to drink more alcohol, had fewer FR failures, and faster completion of FR schedules in adulthood, whereas the low consumers were no different from controls. Rats exposed to ethanol in young adulthood also increased future intake, but there were no differences in any other components of drinking behavior. Both adolescent- and adult-exposed rats did not exhibit an increase in lever pressing during the appetitive challenge session. These data indicate that adolescent and early adult alcohol exposure can increase consumptive aspects of drinking but that adolescent exposure may preferentially influence the motivation to drink.</description><identifier>ISSN: 0741-8329</identifier><identifier>EISSN: 1873-6823</identifier><identifier>DOI: 10.1016/j.alcohol.2016.12.002</identifier><identifier>PMID: 28187948</identifier><identifier>CODEN: ALCOEX</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescence ; Age Factors ; Alcohol ; Alcohol drinking ; Alcohol Drinking - psychology ; Alcohol Drinking - trends ; Animal cognition ; Animals ; Appetitive responses ; Behavior ; Child development ; Conditioning, Operant - drug effects ; Conditioning, Operant - physiology ; Consumptive responses ; Ethanol - administration & dosage ; Grants ; Hypotheses ; Male ; Motivation - drug effects ; Motivation - physiology ; Neurobiology ; Psychiatry ; Rats ; Rats, Wistar ; Rodents ; Self Administration ; Studies ; Wistar rats ; Young adults</subject><ispartof>Alcohol (Fayetteville, N.Y.), 2017-03, Vol.59, p.43-51</ispartof><rights>Elsevier Inc.</rights><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c550t-aa0f6ba053f869b9be3bb75bdd8cddf268c7449e634622f3847c98ac068cceb63</citedby><cites>FETCH-LOGICAL-c550t-aa0f6ba053f869b9be3bb75bdd8cddf268c7449e634622f3847c98ac068cceb63</cites><orcidid>0000-0002-3411-2436</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1874446454?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,315,782,786,887,3552,27931,27932,46002,64392,64394,64396,72476</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28187948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Amodeo, Leslie R</creatorcontrib><creatorcontrib>Kneiber, Diana</creatorcontrib><creatorcontrib>Wills, Derek N</creatorcontrib><creatorcontrib>Ehlers, Cindy L</creatorcontrib><title>Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats</title><title>Alcohol (Fayetteville, N.Y.)</title><addtitle>Alcohol</addtitle><description>Abstract Binge drinking and the onset of alcohol-use disorders usually peak during the transition between late adolescence and early adulthood, and early adolescent onset of alcohol consumption has been demonstrated to increase the risk for alcohol dependence in adulthood. In the present study, we describe an animal model of early adolescent alcohol consumption where animals drink unsweetened and unflavored ethanol in high concentrations (20%). Using this model, we investigated the influence of drinking on alcohol-related appetitive behavior and alcohol consumption levels in early adulthood. Further, we also sought to investigate whether differences in alcohol-related drinking behaviors were specific to exposure in adolescence versus exposure in adulthood. Male Wistar rats were given a 2-bottle choice between 20% ethanol and water in one group and between two water bottles in another group during their adolescence (Postnatal Day [PD] 26–59) to model voluntary drinking in adolescent humans. As young adults (PD85), rats were trained in a paradigm that provided free access to 20% alcohol for 25 min after completing up to a fixed-ratio (FR) 16 lever press response. A set of young adult male Wistar rats was exposed to the same paradigm using the same time course, beginning at PD92. The results indicate that adolescent exposure to alcohol increased consumption of alcohol in adulthood. Furthermore, when investigating differences between adolescent high and low drinkers in adulthood, high consumers continued to drink more alcohol, had fewer FR failures, and faster completion of FR schedules in adulthood, whereas the low consumers were no different from controls. Rats exposed to ethanol in young adulthood also increased future intake, but there were no differences in any other components of drinking behavior. Both adolescent- and adult-exposed rats did not exhibit an increase in lever pressing during the appetitive challenge session. These data indicate that adolescent and early adult alcohol exposure can increase consumptive aspects of drinking but that adolescent exposure may preferentially influence the motivation to drink.</description><subject>Adolescence</subject><subject>Age Factors</subject><subject>Alcohol</subject><subject>Alcohol drinking</subject><subject>Alcohol Drinking - psychology</subject><subject>Alcohol Drinking - trends</subject><subject>Animal cognition</subject><subject>Animals</subject><subject>Appetitive responses</subject><subject>Behavior</subject><subject>Child development</subject><subject>Conditioning, Operant - drug effects</subject><subject>Conditioning, Operant - physiology</subject><subject>Consumptive responses</subject><subject>Ethanol - administration & dosage</subject><subject>Grants</subject><subject>Hypotheses</subject><subject>Male</subject><subject>Motivation - drug effects</subject><subject>Motivation - physiology</subject><subject>Neurobiology</subject><subject>Psychiatry</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Self Administration</subject><subject>Studies</subject><subject>Wistar rats</subject><subject>Young adults</subject><issn>0741-8329</issn><issn>1873-6823</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkktv1DAUhSMEokPhJ4AisWGT4LedTVFV8ZIqsQDE0nJsp-PUEw92MlL_PTeaoUA3rKwbf-fk3ntcVS8xajHC4u3YmmjTNsWWQNli0iJEHlUbrCRthCL0cbVBkuFGUdKdVc9KGRFCUsruaXVGFGAdU5tqvDy61C6H6TZMN7Vb8noYl6Iv1k_W12Gy2ZviS23TVJbdfg4HX2df9lDC1znVp2YABeUS521Kbi1-hDKbXGczl-fVk8HE4l-czvPq-4f3364-NddfPn6-urxuLOdoboxBg-gN4nRQouu73tO-l7x3TlnnBiKUlYx1XlAmCBmoYtJ2ylgEF9b3gp5XF0ff_dLvvIMR5myi3uewM_lOJxP0vzdT2OqbdNCccqWQBIM3J4Ocfi6-zHoXYBMxmsmnpWishORUdrwD9PUDdExLnmA8oKBNJhhnQPEjZXMqJfvhvhmM9JqmHvVpgXpNU2OiIU3Qvfp7knvV7_gAeHcEPOzzEHzWxYY1Mheyt7N2Kfz3FxcPHGwMU7Am3vo7X_5MowsI9Nf1Sa0vCgsKciboLx3ey7Y</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Amodeo, Leslie R</creator><creator>Kneiber, Diana</creator><creator>Wills, Derek N</creator><creator>Ehlers, Cindy L</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7QG</scope><scope>7RV</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AM</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGRYB</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K7.</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0O</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3411-2436</orcidid></search><sort><creationdate>20170301</creationdate><title>Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats</title><author>Amodeo, Leslie R ; Kneiber, Diana ; Wills, Derek N ; Ehlers, Cindy L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c550t-aa0f6ba053f869b9be3bb75bdd8cddf268c7449e634622f3847c98ac068cceb63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescence</topic><topic>Age Factors</topic><topic>Alcohol</topic><topic>Alcohol drinking</topic><topic>Alcohol Drinking - psychology</topic><topic>Alcohol Drinking - trends</topic><topic>Animal cognition</topic><topic>Animals</topic><topic>Appetitive responses</topic><topic>Behavior</topic><topic>Child development</topic><topic>Conditioning, Operant - drug effects</topic><topic>Conditioning, Operant - physiology</topic><topic>Consumptive responses</topic><topic>Ethanol - administration & dosage</topic><topic>Grants</topic><topic>Hypotheses</topic><topic>Male</topic><topic>Motivation - drug effects</topic><topic>Motivation - physiology</topic><topic>Neurobiology</topic><topic>Psychiatry</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Self Administration</topic><topic>Studies</topic><topic>Wistar rats</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amodeo, Leslie R</creatorcontrib><creatorcontrib>Kneiber, Diana</creatorcontrib><creatorcontrib>Wills, Derek N</creatorcontrib><creatorcontrib>Ehlers, Cindy L</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Criminal Justice Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Criminology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Criminal Justice (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Criminal Justice Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amodeo, Leslie R</au><au>Kneiber, Diana</au><au>Wills, Derek N</au><au>Ehlers, Cindy L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats</atitle><jtitle>Alcohol (Fayetteville, N.Y.)</jtitle><addtitle>Alcohol</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>59</volume><spage>43</spage><epage>51</epage><pages>43-51</pages><issn>0741-8329</issn><eissn>1873-6823</eissn><coden>ALCOEX</coden><abstract>Abstract Binge drinking and the onset of alcohol-use disorders usually peak during the transition between late adolescence and early adulthood, and early adolescent onset of alcohol consumption has been demonstrated to increase the risk for alcohol dependence in adulthood. In the present study, we describe an animal model of early adolescent alcohol consumption where animals drink unsweetened and unflavored ethanol in high concentrations (20%). Using this model, we investigated the influence of drinking on alcohol-related appetitive behavior and alcohol consumption levels in early adulthood. Further, we also sought to investigate whether differences in alcohol-related drinking behaviors were specific to exposure in adolescence versus exposure in adulthood. Male Wistar rats were given a 2-bottle choice between 20% ethanol and water in one group and between two water bottles in another group during their adolescence (Postnatal Day [PD] 26–59) to model voluntary drinking in adolescent humans. As young adults (PD85), rats were trained in a paradigm that provided free access to 20% alcohol for 25 min after completing up to a fixed-ratio (FR) 16 lever press response. A set of young adult male Wistar rats was exposed to the same paradigm using the same time course, beginning at PD92. The results indicate that adolescent exposure to alcohol increased consumption of alcohol in adulthood. Furthermore, when investigating differences between adolescent high and low drinkers in adulthood, high consumers continued to drink more alcohol, had fewer FR failures, and faster completion of FR schedules in adulthood, whereas the low consumers were no different from controls. Rats exposed to ethanol in young adulthood also increased future intake, but there were no differences in any other components of drinking behavior. Both adolescent- and adult-exposed rats did not exhibit an increase in lever pressing during the appetitive challenge session. These data indicate that adolescent and early adult alcohol exposure can increase consumptive aspects of drinking but that adolescent exposure may preferentially influence the motivation to drink.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28187948</pmid><doi>10.1016/j.alcohol.2016.12.002</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-3411-2436</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adolescence Age Factors Alcohol Alcohol drinking Alcohol Drinking - psychology Alcohol Drinking - trends Animal cognition Animals Appetitive responses Behavior Child development Conditioning, Operant - drug effects Conditioning, Operant - physiology Consumptive responses Ethanol - administration & dosage Grants Hypotheses Male Motivation - drug effects Motivation - physiology Neurobiology Psychiatry Rats Rats, Wistar Rodents Self Administration Studies Wistar rats Young adults |
title | Alcohol drinking during adolescence increases consumptive responses to alcohol in adulthood in Wistar rats |
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