Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes. Here, we performed forward genetic screening in mice using Sleeping Beauty transposon mutagenesis to identify candi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2017-03, Vol.114 (11), p.E2215-E2224
Hauptverfasser:	Chen, Liming, Jenjaroenpun, Piroon, Pillai, Andrea Mun Ching, Ivshina, Anna V., Ow, Ghim Siong, Efthimios, Motakis, Zhiqun, Tang, Tan, Tuan Zea, Lee, Song-Choon, Rogers, Keith, Ward, Jerrold M., Mori, Seiichi, Adams, David J., Jenkins, Nancy A., Copeland, Neal G., Ban, Kenneth Hon-Kim, Kuznetsov, Vladimir A., Thiery, Jean Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological Sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cell Line, Tumor Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Computational Biology - methods Disease Models, Animal DNA Transposable Elements Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene Regulatory Networks Genes Genetic Association Studies Genetic Predisposition to Disease High-Throughput Nucleotide Sequencing Humans Mice Mice, Knockout Mutagenesis Mutagenesis, Insertional Mutation PNAS Plus Prognosis Proteins Reproducibility of Results Risk Rodents Signal Transduction Survival Analysis Transcriptome
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