Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy
Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in...
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| Veröffentlicht in: | BMC nephrology 2017-03, Vol.18 (1), p.94-94, Article 94 |
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| creator | Han, In Mi Yoon, Chang-Yun Shin, Dong Ho Kee, Youn Kyung Han, Seung Gyu Kwon, Young Eun Park, Kyoung Sook Lee, Mi Jung Oh, Hyung Jung Park, Jung Tak Han, Seung Hyeok Kang, Shin-Wook Yoo, Tae-Hyun |
| description | Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT).
This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients.
Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P |
| doi_str_mv | 10.1186/s12882-017-0507-8 |
| format | Article |
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This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients.
Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036).
This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.</description><identifier>ISSN: 1471-2369</identifier><identifier>EISSN: 1471-2369</identifier><identifier>DOI: 10.1186/s12882-017-0507-8</identifier><identifier>PMID: 28320333</identifier><language>eng</language><publisher>England: BioMed Central</publisher><subject>Acute Kidney Injury - blood ; Acute Kidney Injury - mortality ; Acute Kidney Injury - pathology ; Biomarkers ; Blood ; Causality ; Cytokines ; Female ; Granulocytes - pathology ; Hospitals ; Humans ; Incidence ; Intensive care ; Kidney diseases ; Kidney transplantation ; Leukocyte Count - methods ; Leukocytes (granulocytic) ; Male ; Middle Aged ; Mortality ; Nephrology ; Neutrophils ; Physiology ; Renal replacement therapy ; Renal Replacement Therapy - mortality ; Renal Replacement Therapy - utilization ; Reproducibility of Results ; Republic of Korea - epidemiology ; Retrospective Studies ; Risk Assessment - methods ; Sensitivity and Specificity ; Sepsis ; Sepsis - blood ; Sepsis - mortality ; Sepsis - pathology ; Studies ; Survival Analysis ; Treatment Outcome ; Tumor necrosis factor-TNF</subject><ispartof>BMC nephrology, 2017-03, Vol.18 (1), p.94-94, Article 94</ispartof><rights>Copyright BioMed Central 2017</rights><rights>The Author(s). 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-31c332df18afc3ba68e7f7c7349ba1b704320f97773ea01e776c873a1ac186433</citedby><cites>FETCH-LOGICAL-c427t-31c332df18afc3ba68e7f7c7349ba1b704320f97773ea01e776c873a1ac186433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358045/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5358045/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28320333$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Han, In Mi</creatorcontrib><creatorcontrib>Yoon, Chang-Yun</creatorcontrib><creatorcontrib>Shin, Dong Ho</creatorcontrib><creatorcontrib>Kee, Youn Kyung</creatorcontrib><creatorcontrib>Han, Seung Gyu</creatorcontrib><creatorcontrib>Kwon, Young Eun</creatorcontrib><creatorcontrib>Park, Kyoung Sook</creatorcontrib><creatorcontrib>Lee, Mi Jung</creatorcontrib><creatorcontrib>Oh, Hyung Jung</creatorcontrib><creatorcontrib>Park, Jung Tak</creatorcontrib><creatorcontrib>Han, Seung Hyeok</creatorcontrib><creatorcontrib>Kang, Shin-Wook</creatorcontrib><creatorcontrib>Yoo, Tae-Hyun</creatorcontrib><title>Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy</title><title>BMC nephrology</title><addtitle>BMC Nephrol</addtitle><description>Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT).
This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients.
Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036).
This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.</description><subject>Acute Kidney Injury - blood</subject><subject>Acute Kidney Injury - mortality</subject><subject>Acute Kidney Injury - pathology</subject><subject>Biomarkers</subject><subject>Blood</subject><subject>Causality</subject><subject>Cytokines</subject><subject>Female</subject><subject>Granulocytes - pathology</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Incidence</subject><subject>Intensive care</subject><subject>Kidney diseases</subject><subject>Kidney transplantation</subject><subject>Leukocyte Count - methods</subject><subject>Leukocytes (granulocytic)</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Nephrology</subject><subject>Neutrophils</subject><subject>Physiology</subject><subject>Renal replacement therapy</subject><subject>Renal Replacement Therapy - mortality</subject><subject>Renal Replacement Therapy - utilization</subject><subject>Reproducibility of Results</subject><subject>Republic of Korea - epidemiology</subject><subject>Retrospective Studies</subject><subject>Risk Assessment - methods</subject><subject>Sensitivity and Specificity</subject><subject>Sepsis</subject><subject>Sepsis - blood</subject><subject>Sepsis - mortality</subject><subject>Sepsis - pathology</subject><subject>Studies</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Tumor necrosis factor-TNF</subject><issn>1471-2369</issn><issn>1471-2369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkU2PFCEQhonRuOvqD_BiSLx4aeWjp2EuJmb9TDbxomdSQ1c7jDQg0Or8E3-utLNuVi9FBZ56qaqXkMecPedcDy8KF1qLjnHVsQ1Tnb5DznmveCfksL17Kz8jD0o5sAbqnt0nZ0JLwaSU5-TXa_QVaMCl5pj2zlMXRvxJXaEQ_uQJWwiVpoyjszVmGic6x1zBu3psCC2YqrMU7FKRfnVjwPX6sOQjTVBdKy60ZoSKI_3h6p7aGKoLS1wKzRjAt5g8WJzXf-oeM6TjQ3JvAl_w0fV5QT6_ffPp8n139fHdh8tXV53thaqd5FZKMU5cw2TlDgaNalJWyX67A75TrG-TTlullERgHJUarFYSONi2wV7KC_LypJuW3YyjbS1k8CZlN0M-mgjO_PsS3N58id_NRm406zdN4Nm1QI7fFizVzK5Y9B4CtgkN12o7DExL3dCn_6GHuOS2gJXSkjExKNEofqJsjqVknG6a4cysvpuT76bZaVbfzar85PYUNxV_jZa_AVWCrVQ</recordid><startdate>20170320</startdate><enddate>20170320</enddate><creator>Han, In Mi</creator><creator>Yoon, Chang-Yun</creator><creator>Shin, Dong Ho</creator><creator>Kee, Youn Kyung</creator><creator>Han, Seung Gyu</creator><creator>Kwon, Young Eun</creator><creator>Park, Kyoung Sook</creator><creator>Lee, Mi Jung</creator><creator>Oh, Hyung Jung</creator><creator>Park, Jung Tak</creator><creator>Han, Seung Hyeok</creator><creator>Kang, Shin-Wook</creator><creator>Yoo, Tae-Hyun</creator><general>BioMed Central</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170320</creationdate><title>Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy</title><author>Han, In Mi ; Yoon, Chang-Yun ; Shin, Dong Ho ; Kee, Youn Kyung ; Han, Seung Gyu ; Kwon, Young Eun ; Park, Kyoung Sook ; Lee, Mi Jung ; Oh, Hyung Jung ; Park, Jung Tak ; Han, Seung Hyeok ; Kang, Shin-Wook ; Yoo, Tae-Hyun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-31c332df18afc3ba68e7f7c7349ba1b704320f97773ea01e776c873a1ac186433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acute Kidney Injury - blood</topic><topic>Acute Kidney Injury - mortality</topic><topic>Acute Kidney Injury - pathology</topic><topic>Biomarkers</topic><topic>Blood</topic><topic>Causality</topic><topic>Cytokines</topic><topic>Female</topic><topic>Granulocytes - pathology</topic><topic>Hospitals</topic><topic>Humans</topic><topic>Incidence</topic><topic>Intensive care</topic><topic>Kidney diseases</topic><topic>Kidney transplantation</topic><topic>Leukocyte Count - methods</topic><topic>Leukocytes (granulocytic)</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Nephrology</topic><topic>Neutrophils</topic><topic>Physiology</topic><topic>Renal replacement therapy</topic><topic>Renal Replacement Therapy - mortality</topic><topic>Renal Replacement Therapy - utilization</topic><topic>Reproducibility of Results</topic><topic>Republic of Korea - epidemiology</topic><topic>Retrospective Studies</topic><topic>Risk Assessment - methods</topic><topic>Sensitivity and Specificity</topic><topic>Sepsis</topic><topic>Sepsis - blood</topic><topic>Sepsis - mortality</topic><topic>Sepsis - pathology</topic><topic>Studies</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Han, In Mi</creatorcontrib><creatorcontrib>Yoon, Chang-Yun</creatorcontrib><creatorcontrib>Shin, Dong Ho</creatorcontrib><creatorcontrib>Kee, Youn Kyung</creatorcontrib><creatorcontrib>Han, Seung Gyu</creatorcontrib><creatorcontrib>Kwon, Young Eun</creatorcontrib><creatorcontrib>Park, Kyoung Sook</creatorcontrib><creatorcontrib>Lee, Mi Jung</creatorcontrib><creatorcontrib>Oh, Hyung Jung</creatorcontrib><creatorcontrib>Park, Jung Tak</creatorcontrib><creatorcontrib>Han, Seung Hyeok</creatorcontrib><creatorcontrib>Kang, Shin-Wook</creatorcontrib><creatorcontrib>Yoo, Tae-Hyun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMC nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Han, In Mi</au><au>Yoon, Chang-Yun</au><au>Shin, Dong Ho</au><au>Kee, Youn Kyung</au><au>Han, Seung Gyu</au><au>Kwon, Young Eun</au><au>Park, Kyoung Sook</au><au>Lee, Mi Jung</au><au>Oh, Hyung Jung</au><au>Park, Jung Tak</au><au>Han, Seung Hyeok</au><au>Kang, Shin-Wook</au><au>Yoo, Tae-Hyun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy</atitle><jtitle>BMC nephrology</jtitle><addtitle>BMC Nephrol</addtitle><date>2017-03-20</date><risdate>2017</risdate><volume>18</volume><issue>1</issue><spage>94</spage><epage>94</epage><pages>94-94</pages><artnum>94</artnum><issn>1471-2369</issn><eissn>1471-2369</eissn><abstract>Delta neutrophil index (DNI), representing an elevated fraction of circulating immature granulocytes in acute infection, has been reported as a useful marker for predicting mortality in patients with sepsis. The aim of this study was to evaluate the prognostic value of DNI in predicting mortality in septic acute kidney injury (S-AKI) patients treated with continuous renal replacement therapy (CRRT).
This is a retrospective analysis of consecutively CRRT treated patients. We enrolled 286 S-AKI patients who underwent CRRT and divided them into three groups based on the tertiles of DNI at CRRT initiation (high, DNI > 12.0%; intermediate, 3.6-12.0%; low, < 3.6%). Patient survival was estimated with the Kaplan-Meier method and Cox proportional hazards models to determine the effect of DNI on the mortality of S-AKI patients.
Patients in the highest tertile of DNI showed higher Acute Physiology and Chronic Health Evaluation II score (highest tertile, 27.9 ± 7.0; lowest tertile, 24.6 ± 8.3; P = 0.003) and Sequential Organ Failure Assessment score (highest tertile, 14.1 ± 3.0; lowest tertile, 12.1 ± 4.0; P = 0.001). The 28-day mortality rate was significantly higher in the highest tertile group than in the lower two tertile groups (P < 0.001). In the multiple Cox proportional hazard model, DNI was an independent predictor for mortality after adjusting multiple confounding factors (hazard ratio, 1.010; 95% confidence interval, 1.001-1.019; P = 0.036).
This study suggests that DNI is independently associated with mortality of S-AKI patients on CRRT.</abstract><cop>England</cop><pub>BioMed Central</pub><pmid>28320333</pmid><doi>10.1186/s12882-017-0507-8</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Springer Nature OA/Free Journals; SpringerLink Journals - AutoHoldings; PubMed Central Open Access |
| subjects | Acute Kidney Injury - blood Acute Kidney Injury - mortality Acute Kidney Injury - pathology Biomarkers Blood Causality Cytokines Female Granulocytes - pathology Hospitals Humans Incidence Intensive care Kidney diseases Kidney transplantation Leukocyte Count - methods Leukocytes (granulocytic) Male Middle Aged Mortality Nephrology Neutrophils Physiology Renal replacement therapy Renal Replacement Therapy - mortality Renal Replacement Therapy - utilization Reproducibility of Results Republic of Korea - epidemiology Retrospective Studies Risk Assessment - methods Sensitivity and Specificity Sepsis Sepsis - blood Sepsis - mortality Sepsis - pathology Studies Survival Analysis Treatment Outcome Tumor necrosis factor-TNF |
| title | Delta neutrophil index is an independent predictor of mortality in septic acute kidney injury patients treated with continuous renal replacement therapy |
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