Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity depends on NAD + levels and thus on the cellular metabolic status. SIRTs regulate energy metabolism and mitochondrial function. They orchestrate the stress response and damage repair. Through these functions sirtuins modul...

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Veröffentlicht in:	Neurochemical research 2017-03, Vol.42 (3), p.876-890
Hauptverfasser:	Jęśko, Henryk, Wencel, Przemysław, Strosznajder, Robert P., Strosznajder, Joanna B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - metabolism Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain - metabolism Cell Biology Cell Death Cell Nucleus - metabolism Cell Survival Cytosol - metabolism Energy Metabolism Humans Mitochondria - metabolism Neurochemistry Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - metabolism Neurology Neuroprotection Neuroprotective Agents - therapeutic use Neurosciences Original Paper Signal Transduction Sirtuins - metabolism Somatomedins - metabolism Transcription Factors - metabolism
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