The Association of Vitamin D Deficiency and Incident Frailty in Older Women: The Role of Cardiometabolic Diseases

Objectives Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the vitamin D–frailty association. We aimed to determine the association of vitamin D concentration with incidence...

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Veröffentlicht in:	Journal of the American Geriatrics Society (JAGS) 2017-03, Vol.65 (3), p.619-624
Hauptverfasser:	Buta, Brian, Choudhury, Parichoy Pal, Xue, Qian‐Li, Chaves, Paulo, Bandeen‐Roche, Karen, Shardell, Michelle, Semba, Richard D., Walston, Jeremy, Michos, Erin D., Appel, Lawrence J., McAdams‐DeMarco, Mara, Gross, Alden, Yasar, Sevil, Ferrucci, Luigi, Fried, Linda P., Kalyani, Rita Rastogi
Format:	Artikel
Sprache:	eng
Schlagworte:	25-Hydroxyvitamin D Aged aging Body weight loss cardiometabolic diseases Cardiovascular Diseases - epidemiology Cohort Studies Demography Diabetes mellitus Diabetes Mellitus - epidemiology Female Frail Elderly - statistics & numerical data Frailty Humans Hyperlipidemia Hyperlipidemias - epidemiology Hypertension - epidemiology Incidence Longitudinal Studies Maryland - epidemiology Older people Physical activity Regression analysis Smoking Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - epidemiology Vitamin deficiency Womens health
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Zusammenfassung:	Objectives Evidence suggests vitamin D deficiency is associated with developing frailty. However, cardiometabolic factors are related to both conditions and may confound and/or mediate the vitamin D–frailty association. We aimed to determine the association of vitamin D concentration with incidence of frailty, and the role of cardiometabolic diseases (cardiovascular disease, diabetes, hyperlipidemia, hypertension) in this relationship. Design Prospective longitudinal cohort study (7 visits from 1994–2008). Setting Baltimore, Maryland. Participants Three hundred sixty‐nine women from the Women's Health and Aging Study II aged 70–79 years, free of frailty at baseline. Measurements Serum circulating 25‐hydroxyvitamin D (25[OH]D) concentration was assessed at baseline and categorized as:
ISSN:	0002-8614 1532-5415
DOI:	10.1111/jgs.14677