A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations
[Abstract]: [Objectives]: The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA...
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| Veröffentlicht in: | Journal of Occupational Health 2016-03, Vol.58 (2), p.196-200 |
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| creator | Hata, Akihisa Kurosawa, Hidetoshi Endo, Yoko Yamanaka, Kenzo Fujitani, Noboru Endo, Ginji |
| description | [Abstract]: [Objectives]: The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after seafood consumption. We estimated the urinary iAs+MMA concentration corresponding to iAs exposure. [Methods]: We used data from two arsenic speciation analyses of urine samples from 330 Bangladeshi with oral iAs exposure and 172 Japanese workers without occupational iAs exposure using high-performance liquid chromatography with inductively coupled plasma mass spectrometry. [Results]: iAs, MMA, and DMA, but not arsenobetaine (AsBe), were detected in the urine of the Bangladeshi subjects. The correlation between iAs+MMA+DMA and iAs+MMA was obtained as log (iAs+MMA)=1.038 log (iAs+MMA+DMA)-0.658. Using the regression formula, the iAs+MMA value was calculated as 2.15 and 7.5 μg As/l, corresponding to 3 and 10μg As/m3 of exposures, respectively. In the urine of the Japanese workers, arsenic was mostly excreted as AsBe. We used the 95th percentile of iAs+MMA (12.6μg As/l) as the background value. The sum of the calculated and background values can be used as a biological indicator of iAs exposure. [Conclusion]: We propose 14.8 and 20.1μg As/l of urinary iAs+MMA as the biological indicators of 3 and 10μg As/m3 iAs exposure, respectively. |
| doi_str_mv | 10.1539/joh.15-0241-OA |
| format | Article |
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Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after seafood consumption. We estimated the urinary iAs+MMA concentration corresponding to iAs exposure. [Methods]: We used data from two arsenic speciation analyses of urine samples from 330 Bangladeshi with oral iAs exposure and 172 Japanese workers without occupational iAs exposure using high-performance liquid chromatography with inductively coupled plasma mass spectrometry. [Results]: iAs, MMA, and DMA, but not arsenobetaine (AsBe), were detected in the urine of the Bangladeshi subjects. The correlation between iAs+MMA+DMA and iAs+MMA was obtained as log (iAs+MMA)=1.038 log (iAs+MMA+DMA)-0.658. Using the regression formula, the iAs+MMA value was calculated as 2.15 and 7.5 μg As/l, corresponding to 3 and 10μg As/m3 of exposures, respectively. In the urine of the Japanese workers, arsenic was mostly excreted as AsBe. We used the 95th percentile of iAs+MMA (12.6μg As/l) as the background value. The sum of the calculated and background values can be used as a biological indicator of iAs exposure. [Conclusion]: We propose 14.8 and 20.1μg As/l of urinary iAs+MMA as the biological indicators of 3 and 10μg As/m3 iAs exposure, respectively.</description><identifier>ISSN: 1341-9145</identifier><identifier>ISSN: 1348-9585</identifier><identifier>EISSN: 1348-9585</identifier><identifier>DOI: 10.1539/joh.15-0241-OA</identifier><identifier>PMID: 27010090</identifier><language>eng</language><publisher>Australia: JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</publisher><subject>Adolescent ; Adult ; Aged ; Arsenic ; Arsenic - urine ; Arsenicals - urine ; Bangladesh ; Bioindicators ; Biological monitoring ; Biomarkers - urine ; Biomonitoring ; Chromatography, High Pressure Liquid ; Environmental Exposure - analysis ; Environmental Monitoring - methods ; Exposure ; Female ; Humans ; Indicator organisms ; Indicators ; Japan ; Liquid chromatography ; Male ; Mass Spectrometry ; Mathematical analysis ; Metabolites ; Middle Aged ; Occupational ; Occupational exposure ; Occupational Exposure - analysis ; Occupational health ; Oral exposure ; Original ; Polymethyl methacrylates ; Seafood ; Speciation ; Urine ; Young Adult</subject><ispartof>Journal of Occupational Health, 2016-03, Vol.58 (2), p.196-200</ispartof><rights>2016 Japan Society for Occupational Health</rights><rights>Copyright Japan Science and Technology Agency 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c8009-e15d07707f14b08c4ea2fedff66c8e6e5fd8974343c1bd1e5bfaf6776631c4ce3</citedby><cites>FETCH-LOGICAL-c8009-e15d07707f14b08c4ea2fedff66c8e6e5fd8974343c1bd1e5bfaf6776631c4ce3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356966/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356966/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,1417,27924,27925,45574,45575,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27010090$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hata, Akihisa</creatorcontrib><creatorcontrib>Kurosawa, Hidetoshi</creatorcontrib><creatorcontrib>Endo, Yoko</creatorcontrib><creatorcontrib>Yamanaka, Kenzo</creatorcontrib><creatorcontrib>Fujitani, Noboru</creatorcontrib><creatorcontrib>Endo, Ginji</creatorcontrib><creatorcontrib>Kansai Rosai Hospital</creatorcontrib><creatorcontrib>Graduate School of Risk and Crisis Management</creatorcontrib><creatorcontrib>School of Pharmacy</creatorcontrib><creatorcontrib>Research Center for Occupational Poisoning</creatorcontrib><creatorcontrib>The Institute for Science of Labour</creatorcontrib><creatorcontrib>Department of Medical Risk Management</creatorcontrib><creatorcontrib>Japan Labor Health and Welfare Organization</creatorcontrib><creatorcontrib>Chiba Institute of Science</creatorcontrib><creatorcontrib>Nihon University</creatorcontrib><creatorcontrib>Criminal Investigation Laboratory</creatorcontrib><creatorcontrib>Laboratory of Environmental Toxicology and Carcinogenesis</creatorcontrib><creatorcontrib>Metropolitan Police Department</creatorcontrib><title>A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations</title><title>Journal of Occupational Health</title><addtitle>J Occup Health</addtitle><description>[Abstract]: [Objectives]: The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after seafood consumption. We estimated the urinary iAs+MMA concentration corresponding to iAs exposure. [Methods]: We used data from two arsenic speciation analyses of urine samples from 330 Bangladeshi with oral iAs exposure and 172 Japanese workers without occupational iAs exposure using high-performance liquid chromatography with inductively coupled plasma mass spectrometry. [Results]: iAs, MMA, and DMA, but not arsenobetaine (AsBe), were detected in the urine of the Bangladeshi subjects. The correlation between iAs+MMA+DMA and iAs+MMA was obtained as log (iAs+MMA)=1.038 log (iAs+MMA+DMA)-0.658. Using the regression formula, the iAs+MMA value was calculated as 2.15 and 7.5 μg As/l, corresponding to 3 and 10μg As/m3 of exposures, respectively. In the urine of the Japanese workers, arsenic was mostly excreted as AsBe. We used the 95th percentile of iAs+MMA (12.6μg As/l) as the background value. The sum of the calculated and background values can be used as a biological indicator of iAs exposure. [Conclusion]: We propose 14.8 and 20.1μg As/l of urinary iAs+MMA as the biological indicators of 3 and 10μg As/m3 iAs exposure, respectively.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Arsenic</subject><subject>Arsenic - urine</subject><subject>Arsenicals - urine</subject><subject>Bangladesh</subject><subject>Bioindicators</subject><subject>Biological monitoring</subject><subject>Biomarkers - urine</subject><subject>Biomonitoring</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Environmental Exposure - analysis</subject><subject>Environmental Monitoring - methods</subject><subject>Exposure</subject><subject>Female</subject><subject>Humans</subject><subject>Indicator organisms</subject><subject>Indicators</subject><subject>Japan</subject><subject>Liquid chromatography</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Mathematical analysis</subject><subject>Metabolites</subject><subject>Middle Aged</subject><subject>Occupational</subject><subject>Occupational exposure</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational health</subject><subject>Oral exposure</subject><subject>Original</subject><subject>Polymethyl methacrylates</subject><subject>Seafood</subject><subject>Speciation</subject><subject>Urine</subject><subject>Young Adult</subject><issn>1341-9145</issn><issn>1348-9585</issn><issn>1348-9585</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk1v1DAQhiMEotXSK0cUiQuXFI8df-SCtKqgBVXaC5wtx7F3XSX2YieU_Qn8a5xNKR9C2tPM2M_7ajyeongJ6BIoad7ehV1OKoRrqDbrJ8U5kFpUDRX06TGHqoGanhUXKbkWYQKUAyPPizPMESDUoPPix7psXejD1mnVl853OY4hlsHmIsSt8k6XKiYzR_N9H9IUTTkl57fluDNlmoaZnaLzKh7-o1G-K4fgw2DG3aHPp-F4ql1X6uC18WNUows-vSieWdUnc_EQV8WXD-8_X91Ut5vrj1fr20qL3HJlgHaIc8Qt1C0SujYKW9NZy5gWhhlqO9HwmtREQ9uBoa1VlnHOGAFda0NWxbvFdz-1g-mWDnq5j27IL5BBOfn3jXc7uQ3fJCWUNdlmVbx5MIjh62TSKAeXtOl75U2YkgSBKQUQuYXTKBJMABVwGuUN5hwIJRl9_Q96F6bo89BmigjKiOCZulwoHUNK0djHJwKS8_pk1S4ncl4fuVlnwas_B_OI_1qWDDQLcO96czhhJz9tbjCi-c9wFmft9aLNzvOqBd87b343ri0_5hIjYBLNQpxDIxE0uc4emNG6bij5CYKe6_s</recordid><startdate>201603</startdate><enddate>201603</enddate><creator>Hata, Akihisa</creator><creator>Kurosawa, Hidetoshi</creator><creator>Endo, Yoko</creator><creator>Yamanaka, Kenzo</creator><creator>Fujitani, Noboru</creator><creator>Endo, Ginji</creator><general>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</general><general>John Wiley & Sons, Inc</general><general>Japan Society for Occupational Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7TA</scope><scope>7TB</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>JG9</scope><scope>KR7</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7U2</scope><scope>5PM</scope></search><sort><creationdate>201603</creationdate><title>A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations</title><author>Hata, Akihisa ; Kurosawa, Hidetoshi ; Endo, Yoko ; Yamanaka, Kenzo ; Fujitani, Noboru ; Endo, Ginji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c8009-e15d07707f14b08c4ea2fedff66c8e6e5fd8974343c1bd1e5bfaf6776631c4ce3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Arsenic</topic><topic>Arsenic - urine</topic><topic>Arsenicals - urine</topic><topic>Bangladesh</topic><topic>Bioindicators</topic><topic>Biological monitoring</topic><topic>Biomarkers - urine</topic><topic>Biomonitoring</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Environmental Exposure - analysis</topic><topic>Environmental Monitoring - methods</topic><topic>Exposure</topic><topic>Female</topic><topic>Humans</topic><topic>Indicator organisms</topic><topic>Indicators</topic><topic>Japan</topic><topic>Liquid chromatography</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Mathematical analysis</topic><topic>Metabolites</topic><topic>Middle Aged</topic><topic>Occupational</topic><topic>Occupational exposure</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational health</topic><topic>Oral exposure</topic><topic>Original</topic><topic>Polymethyl methacrylates</topic><topic>Seafood</topic><topic>Speciation</topic><topic>Urine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hata, Akihisa</creatorcontrib><creatorcontrib>Kurosawa, Hidetoshi</creatorcontrib><creatorcontrib>Endo, Yoko</creatorcontrib><creatorcontrib>Yamanaka, Kenzo</creatorcontrib><creatorcontrib>Fujitani, Noboru</creatorcontrib><creatorcontrib>Endo, Ginji</creatorcontrib><creatorcontrib>Kansai Rosai Hospital</creatorcontrib><creatorcontrib>Graduate School of Risk and Crisis Management</creatorcontrib><creatorcontrib>School of Pharmacy</creatorcontrib><creatorcontrib>Research Center for Occupational Poisoning</creatorcontrib><creatorcontrib>The Institute for Science of Labour</creatorcontrib><creatorcontrib>Department of Medical Risk Management</creatorcontrib><creatorcontrib>Japan Labor Health and Welfare Organization</creatorcontrib><creatorcontrib>Chiba Institute of Science</creatorcontrib><creatorcontrib>Nihon University</creatorcontrib><creatorcontrib>Criminal Investigation Laboratory</creatorcontrib><creatorcontrib>Laboratory of Environmental Toxicology and Carcinogenesis</creatorcontrib><creatorcontrib>Metropolitan Police Department</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Materials Business File</collection><collection>Mechanical & Transportation Engineering Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Materials Research Database</collection><collection>Civil Engineering Abstracts</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Safety Science and Risk</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Occupational Health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hata, Akihisa</au><au>Kurosawa, Hidetoshi</au><au>Endo, Yoko</au><au>Yamanaka, Kenzo</au><au>Fujitani, Noboru</au><au>Endo, Ginji</au><aucorp>Kansai Rosai Hospital</aucorp><aucorp>Graduate School of Risk and Crisis Management</aucorp><aucorp>School of Pharmacy</aucorp><aucorp>Research Center for Occupational Poisoning</aucorp><aucorp>The Institute for Science of Labour</aucorp><aucorp>Department of Medical Risk Management</aucorp><aucorp>Japan Labor Health and Welfare Organization</aucorp><aucorp>Chiba Institute of Science</aucorp><aucorp>Nihon University</aucorp><aucorp>Criminal Investigation Laboratory</aucorp><aucorp>Laboratory of Environmental Toxicology and Carcinogenesis</aucorp><aucorp>Metropolitan Police Department</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations</atitle><jtitle>Journal of Occupational Health</jtitle><addtitle>J Occup Health</addtitle><date>2016-03</date><risdate>2016</risdate><volume>58</volume><issue>2</issue><spage>196</spage><epage>200</epage><pages>196-200</pages><issn>1341-9145</issn><issn>1348-9585</issn><eissn>1348-9585</eissn><abstract>[Abstract]: [Objectives]: The sum of urinary inorganic arsenic (iAs), monomethylarsonic acid (MMA), and dimethylarsinic acid (DMA) concentrations is used for the biological monitoring of occupational iAs exposure. Although DMA is a major metabolite of iAs, it is an inadequate index because high DMA levels are present in urine after seafood consumption. We estimated the urinary iAs+MMA concentration corresponding to iAs exposure. [Methods]: We used data from two arsenic speciation analyses of urine samples from 330 Bangladeshi with oral iAs exposure and 172 Japanese workers without occupational iAs exposure using high-performance liquid chromatography with inductively coupled plasma mass spectrometry. [Results]: iAs, MMA, and DMA, but not arsenobetaine (AsBe), were detected in the urine of the Bangladeshi subjects. The correlation between iAs+MMA+DMA and iAs+MMA was obtained as log (iAs+MMA)=1.038 log (iAs+MMA+DMA)-0.658. Using the regression formula, the iAs+MMA value was calculated as 2.15 and 7.5 μg As/l, corresponding to 3 and 10μg As/m3 of exposures, respectively. In the urine of the Japanese workers, arsenic was mostly excreted as AsBe. We used the 95th percentile of iAs+MMA (12.6μg As/l) as the background value. The sum of the calculated and background values can be used as a biological indicator of iAs exposure. [Conclusion]: We propose 14.8 and 20.1μg As/l of urinary iAs+MMA as the biological indicators of 3 and 10μg As/m3 iAs exposure, respectively.</abstract><cop>Australia</cop><pub>JAPAN SOCIETY FOR OCCUPATIONAL HEALTH</pub><pmid>27010090</pmid><doi>10.1539/joh.15-0241-OA</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Arsenic Arsenic - urine Arsenicals - urine Bangladesh Bioindicators Biological monitoring Biomarkers - urine Biomonitoring Chromatography, High Pressure Liquid Environmental Exposure - analysis Environmental Monitoring - methods Exposure Female Humans Indicator organisms Indicators Japan Liquid chromatography Male Mass Spectrometry Mathematical analysis Metabolites Middle Aged Occupational Occupational exposure Occupational Exposure - analysis Occupational health Oral exposure Original Polymethyl methacrylates Seafood Speciation Urine Young Adult |
| title | A biological indicator of inorganic arsenic exposure using the sum of urinary inorganic arsenic and monomethylarsonic acid concentrations |
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