LEF1 reduces tumor progression and induces myodifferentiation in a subset of rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and show characteristics of skeletal muscle differentiation. The two major RMS subtypes in children are alveolar (ARMS) and embryonal RMS (ERMS). We demonstrate that approximately 50% of ARMS and ERMS overexpress the LEF1/TCF...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (2), p.3259-3273
Hauptverfasser:	Dräger, Julia, Simon-Keller, Katja, Pukrop, Tobias, Klemm, Florian, Wilting, Jörg, Sticht, Carsten, Dittmann, Kai, Schulz, Matthias, Leuschner, Ivo, Marx, Alexander, Hahn, Heidi
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Biomarkers, Tumor Biopsy Cell Differentiation - genetics Cell Line, Tumor Cell Movement - genetics Cell Proliferation Disease Progression Gene Expression Gene Knockdown Techniques Humans Lymphoid Enhancer-Binding Factor 1 - genetics Lymphoid Enhancer-Binding Factor 1 - metabolism Neoplasm Grading Research Paper Rhabdomyosarcoma - genetics Rhabdomyosarcoma - metabolism Rhabdomyosarcoma - pathology Tissue Array Analysis Wnt Signaling Pathway
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