Induction of mitochondria-mediated apoptosis and PI3K/Akt/ mTOR-mediated autophagy by aflatoxin B2 in hepatocytes of broilers

Aflatoxins have been shown to induce hepatotoxicity in animal models, but the effects of aflatoxin B2 (AFB2) on broiler hepatocytes is unclear. This study aimed to investigate the effects of AFB2 on apoptosis and autophagy to provide an experimental basis for understanding the mechanism of aflatoxin...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncotarget 2016-12, Vol.7 (51), p.84989-84998
Hauptverfasser:	Chen, Binlong, Li, Diyan, Li, Miao, Li, Sichen, Peng, Kenan, Shi, Xian, Zhou, Lanyun, Zhang, Pu, Xu, Zhongxian, Yin, Huadong, Wang, Yan, Zhao, Xiaoling, Zhu, Qing
Format:	Artikel
Sprache:	eng
Schlagworte:	Aflatoxins - metabolism Animals Apoptosis Autophagy Avian Proteins - metabolism Beclin-1 - metabolism Caspase 3 - metabolism Cells, Cultured Chickens Hepatocytes - physiology Microtubule-Associated Proteins - metabolism Mitochondria - physiology Phosphatidylinositol 3-Kinases - metabolism Poly(ADP-ribose) Polymerases - metabolism Proto-Oncogene Proteins c-akt - metabolism Reactive Oxygen Species Research Paper RNA-Binding Proteins - metabolism Signal Transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!