NFI and Oct-1 bend the Ad5 origin in the same direction leading to optimal DNA replication

Two cellular transcription factors, nuclear factor I (NFI) and octamer binding protein (Oct-1), bind simultaneously to their recognition sequences in the Ad5 origin of replication thereby enhancing initiation. Using scanning force microscopy we have previously shown that NFI induces a 60° bend in th...

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Veröffentlicht in:	Nucleic acids research 2004-01, Vol.32 (21), p.6218-6225
Hauptverfasser:	Mysiak, Monika E., Wyman, Claire, Holthuizen, P. Elly, van der Vliet, Peter C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenoviridae - genetics Binding Sites CCAAT-Enhancer-Binding Proteins - metabolism DNA Replication DNA, Viral - biosynthesis DNA, Viral - chemistry DNA, Viral - ultrastructure DNA-Binding Proteins - metabolism Microscopy, Atomic Force NFI Transcription Factors Nucleic Acid Conformation Octamer Transcription Factor-1 Replication Origin Transcription Factors - metabolism Virus Replication
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