CB2 cannabinoid receptor activation promotes colon cancer progression via AKT/GSK3β signaling pathway

The pharmacological activation of the cannabinoid receptor type 2, CB2, has been shown to elicit anti-tumoral mechanisms in different cancer types. However, little is known about its endogenous role in tumor pathophysiology, and different studies have attributed pro-tumorigenic properties to this re...

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Veröffentlicht in:	Oncotarget 2016-10, Vol.7 (42), p.68781-68791
Hauptverfasser:	Martínez-Martínez, Esther, Martín-Ruiz, Asunción, Martín, Paloma, Calvo, Virginia, Provencio, Mariano, García, José M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, CD Apoptosis Cadherins - metabolism Cannabinoids - chemistry Cell Line, Tumor Cell Membrane - metabolism Cell Proliferation Cell Survival Colonic Neoplasms - drug therapy Colonic Neoplasms - pathology Disease Progression Enzyme Activation Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Glycogen Synthase Kinase 3 beta - metabolism HT29 Cells Humans Mice Mice, Nude Microscopy, Confocal Neoplasm Transplantation Proto-Oncogene Proteins c-akt - metabolism Receptor, Cannabinoid, CB2 - agonists Receptor, Cannabinoid, CB2 - metabolism Research Paper Signal Transduction
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