Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin‐Dependent Effects on Platelet Aggregation Pathways

Genetic variation in the platelet endothelial aggregation receptor 1 (PEAR1) gene, most notably rs12041331, is implicated in altered on‐aspirin platelet aggregation and increased cardiovascular event risk. We prospectively tested the effects of aspirin administration at commonly prescribed doses (81...

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Veröffentlicht in:	Clinical and translational science 2017-03, Vol.10 (2), p.102-109
Hauptverfasser:	Backman, JD, Yerges‐Armstrong, LM, Horenstein, RB, Newcomer, S, Shaub, S, Morrisey, M, Donnelly, P, Drolet, M, Tanner, K, Pavlovich, MA, O'Connell, JR, Mitchell, BD, Lewis, JP
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Adenosine diphosphate Adenosine Diphosphate - pharmacology Adult Alleles Amish - genetics Aspirin Aspirin - pharmacology Biomarkers - urine Blood platelets Blood Platelets - drug effects Blood Platelets - metabolism Cardiovascular disease Cardiovascular diseases Collagen Collagen - pharmacology Drug dosages Endothelium Epinephrine Epinephrine - pharmacology Female Genetic diversity Genotype Genotype & phenotype Genotypes Health risks Healthy Volunteers Humans Influence Intervention Male Middle Aged Platelet aggregation Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - pharmacology Polymorphism, Single Nucleotide Prospective Studies Receptors, Cell Surface - genetics Studies Thromboxane B2 - urine
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