IL-17 contributed to the neuropathic pain following peripheral nerve injury by promoting astrocyte proliferation and secretion of proinflammatory cytokines

Central neuroinflammation is important in the pathophysiological processes of neuropathic pain following peripheral nerve injury. Recently, interleukin-17 (IL-17) has been detected in different inflammatory conditions of the central nervous system and contributes to neuropathic pain associated with...

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Veröffentlicht in:	Molecular medicine reports 2017-01, Vol.15 (1), p.89-96
Hauptverfasser:	Sun, Caixia, Zhang, Jin, Chen, Li, Liu, Tanghua, Xu, Gaobing, Li, Chunye, Yuan, Wen, Xu, Huaxi, Su, Zhaoliang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Astrocytes Astrocytes - immunology Astrocytes - pathology CD4 antigen CD4-Positive T-Lymphocytes - immunology CD4-Positive T-Lymphocytes - pathology Cell activation Cell Proliferation Central nervous system Cytokines Cytokines - immunology Disease Dorsal horn Experimental allergic encephalomyelitis Gene expression Genetic aspects Health aspects Humidity IL-17 Immunofluorescence Inflammation Inflammatory diseases Interleukin 17 Interleukin 6 Interleukin-17 - immunology Ischemia Lymphocytes Lymphocytes T Male model of spinal nerve ligation Multiple sclerosis Neuralgia - etiology Neuralgia - immunology Neuralgia - pathology neuropathic pain Nociception Pain Peripheral Nerve Injuries - complications Peripheral Nerve Injuries - immunology Peripheral Nerve Injuries - pathology Peripheral neuropathy rat Rats, Sprague-Dawley Rodents Spinal cord Spinal Cord Dorsal Horn - immunology Spinal Cord Dorsal Horn - pathology Studies Surgery Th17 Cells - immunology Th17 Cells - pathology Tumor necrosis factor-TNF
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