Multiscale Modeling of Complex Formation and CD80 Depletion during Immune Synapse Development

The mechanisms that discriminate self- and foreign antigen before T cell activation are unresolved. As part of the immune system’s adaptive response to specific infections or neoplasms, antigen-presenting cells (APC) and effector T cells form transcellular molecular complexes. CTLA4 expression on re...

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Veröffentlicht in:	Biophysical journal 2017-03, Vol.112 (5), p.997-1009
Hauptverfasser:	Sugár, István P., Das, Jayajit, Jayaprakash, Ciriyam, Sealfon, Stuart C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens B7-1 Antigen - metabolism Biophysics Cell Biophysics Cells CTLA-4 Antigen - metabolism Immune system Immunological Synapses - metabolism Lymphocytes Models, Biological
Online-Zugang:	Volltext
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