LINE-1 hypomethylation status of circulating cell-free DNA in plasma as a biomarker for colorectal cancer

Colorectal cancer (CRC) is a serious public health problem and non-invasive biomarkers improving diagnosis or therapy are strongly required. Circulating cell-free DNA (cfDNA) has been a promising target for this purpose. In this study, we evaluated the potential of long interspersed nuclear element-...

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Veröffentlicht in:	Oncotarget 2017-02, Vol.8 (7), p.11906-11916
Hauptverfasser:	Nagai, Yuzo, Sunami, Eiji, Yamamoto, Yoko, Hata, Keisuke, Okada, Satoshi, Murono, Koji, Yasuda, Koji, Otani, Kensuke, Nishikawa, Takeshi, Tanaka, Toshiaki, Kiyomatsu, Tomomichi, Kawai, Kazushige, Nozawa, Hiroaki, Ishihara, Soichiro, Hoon, Dave S B, Watanabe, Toshiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomarkers, Tumor - blood Biomarkers, Tumor - genetics Colorectal Neoplasms - blood Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Disease Progression DNA Methylation DNA, Neoplasm - blood Female Humans Long Interspersed Nucleotide Elements Male Prognosis Research Paper
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