GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer
Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis. Relevant studies were searched through predefined strategies, haza...
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| Veröffentlicht in: | Oncotarget 2017-02, Vol.8 (7), p.11788-11796 |
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| creator | Yang, Jing Wen, Jing Tian, Tian Lu, Zhongsheng Wang, Yao Wang, Zikai Wang, Xiangdong Yang, Yunsheng |
| description | Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis.
Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures.
A total of 14 studies with 2,077 patients were included in this meta-analysis. The results showed that GLUT-1 was not significantly associated with overall survival (OS) (HR=1.28, 95% CI=0.86-1.91, p=0.22) or disease-free survival (DFS) (HR=1.71, 95% CI=0.78-3.72, p=0.179). However, subgroup analysis indicated that GLUT-1 was a significant biomarker for poor DFS in rectal cancer (HR=2.47, 95% CI=1.21-5.05, p=0.013). GLUT-1 expression was also found to be significantly correlated with the presence of lymph node metastasis (n=8, OR=2.14, 95% CI=1.66-2.75, p |
| doi_str_mv | 10.18632/oncotarget.14352 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5355304</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1855787328</sourcerecordid><originalsourceid>FETCH-LOGICAL-c356t-6d111c86494d7fca9845d1df919ea066854a0cd49f40069b1cef9aa61ea2fb8b3</originalsourceid><addsrcrecordid>eNpVUcFqGzEQFSWlCWk-oJeiYy7rSCtpLV0KxaROwNCLfRaz2llH7VraSrKT_H2XOEnduczAvPfmMY-QL5zNuG5EfRODiwXSFsuMS6HqD-SCG2mqWilxdjKfk6ucf7GplJzr2nwi57VmqmZCXBC7XG3WFafxgAmfxoQ5-xgoZAqB7kMPh5igHZCOKW5DzMU72vq4g_QbE_WBjlA8hpLpoy8P1MUhJnQFBuogOEyfyccehoxXr_2SbH7crhd31ern8n7xfVU5oZpSNR3n3OlGGtnNewdGS9XxrjfcILCm0UoCc500vWSsMS132BuAhiPUfatbcUm-HXXHfbvDzk2WEgx2TH6y-mwjePv_JvgHu40Hq8T0IiYngetXgRT_7DEXu_PZ4TBAwLjPlmul5nouaj1B-RHqUsw5Yf9-hjP7ko39l419yWbifD319854S0L8BefgkCA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1855787328</pqid></control><display><type>article</type><title>GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free E- Journals</source><creator>Yang, Jing ; Wen, Jing ; Tian, Tian ; Lu, Zhongsheng ; Wang, Yao ; Wang, Zikai ; Wang, Xiangdong ; Yang, Yunsheng</creator><creatorcontrib>Yang, Jing ; Wen, Jing ; Tian, Tian ; Lu, Zhongsheng ; Wang, Yao ; Wang, Zikai ; Wang, Xiangdong ; Yang, Yunsheng</creatorcontrib><description>Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis.
Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures.
A total of 14 studies with 2,077 patients were included in this meta-analysis. The results showed that GLUT-1 was not significantly associated with overall survival (OS) (HR=1.28, 95% CI=0.86-1.91, p=0.22) or disease-free survival (DFS) (HR=1.71, 95% CI=0.78-3.72, p=0.179). However, subgroup analysis indicated that GLUT-1 was a significant biomarker for poor DFS in rectal cancer (HR=2.47, 95% CI=1.21-5.05, p=0.013). GLUT-1 expression was also found to be significantly correlated with the presence of lymph node metastasis (n=8, OR=2.14, 95% CI=1.66-2.75, p<0.001), T stage (n=6, OR=1.73, 95% CI=1.17-2.58, p=0.007), higher Dukes stage (n=5, OR=2.92, 95% CI=2.16-3.95, p<0.001), female sex (n=4, OR=2.92, 95% CI=2.16-3.95, p<0.001), and presence of liver metastasis (n=3, OR=1.82, 95% CI=1.06-3.12, p=0.03).
In conclusion, this meta-analysis showed that GLUT-1 was associated with poor DFS in rectal cancer (RC). Furthermore, GLUT-1 was also an indicator of aggressive clinical features in CRC.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.14352</identifier><identifier>PMID: 28052033</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - mortality ; Colorectal Neoplasms - pathology ; Glucose Transporter Type 1 - biosynthesis ; Humans ; Prognosis ; Research Paper ; Survival Analysis</subject><ispartof>Oncotarget, 2017-02, Vol.8 (7), p.11788-11796</ispartof><rights>Copyright: © 2017 Yang et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-6d111c86494d7fca9845d1df919ea066854a0cd49f40069b1cef9aa61ea2fb8b3</citedby><cites>FETCH-LOGICAL-c356t-6d111c86494d7fca9845d1df919ea066854a0cd49f40069b1cef9aa61ea2fb8b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355304/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355304/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28052033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Wen, Jing</creatorcontrib><creatorcontrib>Tian, Tian</creatorcontrib><creatorcontrib>Lu, Zhongsheng</creatorcontrib><creatorcontrib>Wang, Yao</creatorcontrib><creatorcontrib>Wang, Zikai</creatorcontrib><creatorcontrib>Wang, Xiangdong</creatorcontrib><creatorcontrib>Yang, Yunsheng</creatorcontrib><title>GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis.
Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures.
A total of 14 studies with 2,077 patients were included in this meta-analysis. The results showed that GLUT-1 was not significantly associated with overall survival (OS) (HR=1.28, 95% CI=0.86-1.91, p=0.22) or disease-free survival (DFS) (HR=1.71, 95% CI=0.78-3.72, p=0.179). However, subgroup analysis indicated that GLUT-1 was a significant biomarker for poor DFS in rectal cancer (HR=2.47, 95% CI=1.21-5.05, p=0.013). GLUT-1 expression was also found to be significantly correlated with the presence of lymph node metastasis (n=8, OR=2.14, 95% CI=1.66-2.75, p<0.001), T stage (n=6, OR=1.73, 95% CI=1.17-2.58, p=0.007), higher Dukes stage (n=5, OR=2.92, 95% CI=2.16-3.95, p<0.001), female sex (n=4, OR=2.92, 95% CI=2.16-3.95, p<0.001), and presence of liver metastasis (n=3, OR=1.82, 95% CI=1.06-3.12, p=0.03).
In conclusion, this meta-analysis showed that GLUT-1 was associated with poor DFS in rectal cancer (RC). Furthermore, GLUT-1 was also an indicator of aggressive clinical features in CRC.</description><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - mortality</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Glucose Transporter Type 1 - biosynthesis</subject><subject>Humans</subject><subject>Prognosis</subject><subject>Research Paper</subject><subject>Survival Analysis</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUcFqGzEQFSWlCWk-oJeiYy7rSCtpLV0KxaROwNCLfRaz2llH7VraSrKT_H2XOEnduczAvPfmMY-QL5zNuG5EfRODiwXSFsuMS6HqD-SCG2mqWilxdjKfk6ucf7GplJzr2nwi57VmqmZCXBC7XG3WFafxgAmfxoQ5-xgoZAqB7kMPh5igHZCOKW5DzMU72vq4g_QbE_WBjlA8hpLpoy8P1MUhJnQFBuogOEyfyccehoxXr_2SbH7crhd31ern8n7xfVU5oZpSNR3n3OlGGtnNewdGS9XxrjfcILCm0UoCc500vWSsMS132BuAhiPUfatbcUm-HXXHfbvDzk2WEgx2TH6y-mwjePv_JvgHu40Hq8T0IiYngetXgRT_7DEXu_PZ4TBAwLjPlmul5nouaj1B-RHqUsw5Yf9-hjP7ko39l419yWbifD319854S0L8BefgkCA</recordid><startdate>20170214</startdate><enddate>20170214</enddate><creator>Yang, Jing</creator><creator>Wen, Jing</creator><creator>Tian, Tian</creator><creator>Lu, Zhongsheng</creator><creator>Wang, Yao</creator><creator>Wang, Zikai</creator><creator>Wang, Xiangdong</creator><creator>Yang, Yunsheng</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170214</creationdate><title>GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer</title><author>Yang, Jing ; Wen, Jing ; Tian, Tian ; Lu, Zhongsheng ; Wang, Yao ; Wang, Zikai ; Wang, Xiangdong ; Yang, Yunsheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-6d111c86494d7fca9845d1df919ea066854a0cd49f40069b1cef9aa61ea2fb8b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - mortality</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Glucose Transporter Type 1 - biosynthesis</topic><topic>Humans</topic><topic>Prognosis</topic><topic>Research Paper</topic><topic>Survival Analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Yang, Jing</creatorcontrib><creatorcontrib>Wen, Jing</creatorcontrib><creatorcontrib>Tian, Tian</creatorcontrib><creatorcontrib>Lu, Zhongsheng</creatorcontrib><creatorcontrib>Wang, Yao</creatorcontrib><creatorcontrib>Wang, Zikai</creatorcontrib><creatorcontrib>Wang, Xiangdong</creatorcontrib><creatorcontrib>Yang, Yunsheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Jing</au><au>Wen, Jing</au><au>Tian, Tian</au><au>Lu, Zhongsheng</au><au>Wang, Yao</au><au>Wang, Zikai</au><au>Wang, Xiangdong</au><au>Yang, Yunsheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-02-14</date><risdate>2017</risdate><volume>8</volume><issue>7</issue><spage>11788</spage><epage>11796</epage><pages>11788-11796</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Glucose transporter-1 (GLUT-1) exhibits altered expression in colorectal cancer (CRC). The aim of this study was to explore the association between GLUT-1 and survival conditions, as well as clinical features in CRC by meta-analysis.
Relevant studies were searched through predefined strategies, hazard ratios (HRs), odds ratios (ORs), and their 95% confidence intervals (CIs) were used as effective measures.
A total of 14 studies with 2,077 patients were included in this meta-analysis. The results showed that GLUT-1 was not significantly associated with overall survival (OS) (HR=1.28, 95% CI=0.86-1.91, p=0.22) or disease-free survival (DFS) (HR=1.71, 95% CI=0.78-3.72, p=0.179). However, subgroup analysis indicated that GLUT-1 was a significant biomarker for poor DFS in rectal cancer (HR=2.47, 95% CI=1.21-5.05, p=0.013). GLUT-1 expression was also found to be significantly correlated with the presence of lymph node metastasis (n=8, OR=2.14, 95% CI=1.66-2.75, p<0.001), T stage (n=6, OR=1.73, 95% CI=1.17-2.58, p=0.007), higher Dukes stage (n=5, OR=2.92, 95% CI=2.16-3.95, p<0.001), female sex (n=4, OR=2.92, 95% CI=2.16-3.95, p<0.001), and presence of liver metastasis (n=3, OR=1.82, 95% CI=1.06-3.12, p=0.03).
In conclusion, this meta-analysis showed that GLUT-1 was associated with poor DFS in rectal cancer (RC). Furthermore, GLUT-1 was also an indicator of aggressive clinical features in CRC.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28052033</pmid><doi>10.18632/oncotarget.14352</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Colorectal Neoplasms - metabolism Colorectal Neoplasms - mortality Colorectal Neoplasms - pathology Glucose Transporter Type 1 - biosynthesis Humans Prognosis Research Paper Survival Analysis |
| title | GLUT-1 overexpression as an unfavorable prognostic biomarker in patients with colorectal cancer |
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