Induction of specific T helper-9 cells to inhibit glioma cell growth
The effects of Staphylococcal enterotoxin B (SEB) on regulation of immune response have been recognized; whether SEB can enhance the effects of immunotherapy on glioma remains to be investigated. This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherap...
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| Veröffentlicht in: | Oncotarget 2017-01, Vol.8 (3), p.4864-4874 |
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| creator | Zheng, Haiyan Yang, Baohua Xu, Dedong Wang, Wenbo Tan, Jie Sun, Liyuan Li, Qinghua Sun, Li Xia, Xuewei |
| description | The effects of Staphylococcal enterotoxin B (SEB) on regulation of immune response have been recognized; whether SEB can enhance the effects of immunotherapy on glioma remains to be investigated. This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherapy on glioma growth in mice. In this study, a glioma-bearing mouse model was developed by adoptive transfer with GL261 cells (a mouse glioma cell line). The mice were treated with the GL261 cell extracts (used as an Ag) with or without administration of SEB. We observed that treating glioma-bearing mice with the glioma Ag and SEB induced glioma-specific Th9 cells in both glioma tissue and the spleen. Treating CD4+ CD25- T cells with SEB increased p300 phosphorylation, histone H3K4 acetylation at the interleukin (IL)-9 promoter locus, and increased the IL-9 transcriptional factor binding to the IL-9 promoter. Treating CD4+ CD25- T cells with both SEB and glioma Ag induced glioma-specific Th9 cells. The glioma-specific Th9 cells induced glioma cell apoptosis in the culture. Treating the glioma-bearing mice with SEB and glioma Ag significantly inhibited the glioma growth. In conclusion, SEB plus glioma Ag immunotherapy inhibits the experimental glioma growth, which may be a novel therapeutic remedy for the treatment of glioma. |
| doi_str_mv | 10.18632/oncotarget.13981 |
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This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherapy on glioma growth in mice. In this study, a glioma-bearing mouse model was developed by adoptive transfer with GL261 cells (a mouse glioma cell line). The mice were treated with the GL261 cell extracts (used as an Ag) with or without administration of SEB. We observed that treating glioma-bearing mice with the glioma Ag and SEB induced glioma-specific Th9 cells in both glioma tissue and the spleen. Treating CD4+ CD25- T cells with SEB increased p300 phosphorylation, histone H3K4 acetylation at the interleukin (IL)-9 promoter locus, and increased the IL-9 transcriptional factor binding to the IL-9 promoter. Treating CD4+ CD25- T cells with both SEB and glioma Ag induced glioma-specific Th9 cells. The glioma-specific Th9 cells induced glioma cell apoptosis in the culture. Treating the glioma-bearing mice with SEB and glioma Ag significantly inhibited the glioma growth. In conclusion, SEB plus glioma Ag immunotherapy inhibits the experimental glioma growth, which may be a novel therapeutic remedy for the treatment of glioma.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.13981</identifier><identifier>PMID: 28002799</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Adoptive Transfer - methods ; Animals ; Antigens, Neoplasm - administration & dosage ; Apoptosis ; Brain Neoplasms - immunology ; Brain Neoplasms - therapy ; CD4-Positive T-Lymphocytes - metabolism ; Cell Line, Tumor ; Combined Modality Therapy ; Enterotoxins - administration & dosage ; Enterotoxins - pharmacology ; Glioma - immunology ; Glioma - therapy ; Interleukin-9 - metabolism ; Male ; Mice ; Research Paper ; T-Lymphocytes, Helper-Inducer - metabolism ; Treatment Outcome ; Xenograft Model Antitumor Assays</subject><ispartof>Oncotarget, 2017-01, Vol.8 (3), p.4864-4874</ispartof><rights>Copyright: © 2017 Zheng et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-3c6dc139c263dc49096f20411dc1347a9b6d8837e06d85586634beb5469eb8d43</citedby><cites>FETCH-LOGICAL-c356t-3c6dc139c263dc49096f20411dc1347a9b6d8837e06d85586634beb5469eb8d43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354876/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354876/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28002799$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zheng, Haiyan</creatorcontrib><creatorcontrib>Yang, Baohua</creatorcontrib><creatorcontrib>Xu, Dedong</creatorcontrib><creatorcontrib>Wang, Wenbo</creatorcontrib><creatorcontrib>Tan, Jie</creatorcontrib><creatorcontrib>Sun, Liyuan</creatorcontrib><creatorcontrib>Li, Qinghua</creatorcontrib><creatorcontrib>Sun, Li</creatorcontrib><creatorcontrib>Xia, Xuewei</creatorcontrib><title>Induction of specific T helper-9 cells to inhibit glioma cell growth</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>The effects of Staphylococcal enterotoxin B (SEB) on regulation of immune response have been recognized; whether SEB can enhance the effects of immunotherapy on glioma remains to be investigated. This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherapy on glioma growth in mice. In this study, a glioma-bearing mouse model was developed by adoptive transfer with GL261 cells (a mouse glioma cell line). The mice were treated with the GL261 cell extracts (used as an Ag) with or without administration of SEB. We observed that treating glioma-bearing mice with the glioma Ag and SEB induced glioma-specific Th9 cells in both glioma tissue and the spleen. Treating CD4+ CD25- T cells with SEB increased p300 phosphorylation, histone H3K4 acetylation at the interleukin (IL)-9 promoter locus, and increased the IL-9 transcriptional factor binding to the IL-9 promoter. Treating CD4+ CD25- T cells with both SEB and glioma Ag induced glioma-specific Th9 cells. The glioma-specific Th9 cells induced glioma cell apoptosis in the culture. Treating the glioma-bearing mice with SEB and glioma Ag significantly inhibited the glioma growth. In conclusion, SEB plus glioma Ag immunotherapy inhibits the experimental glioma growth, which may be a novel therapeutic remedy for the treatment of glioma.</description><subject>Adoptive Transfer - methods</subject><subject>Animals</subject><subject>Antigens, Neoplasm - administration & dosage</subject><subject>Apoptosis</subject><subject>Brain Neoplasms - immunology</subject><subject>Brain Neoplasms - therapy</subject><subject>CD4-Positive T-Lymphocytes - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Combined Modality Therapy</subject><subject>Enterotoxins - administration & dosage</subject><subject>Enterotoxins - pharmacology</subject><subject>Glioma - immunology</subject><subject>Glioma - therapy</subject><subject>Interleukin-9 - metabolism</subject><subject>Male</subject><subject>Mice</subject><subject>Research Paper</subject><subject>T-Lymphocytes, Helper-Inducer - metabolism</subject><subject>Treatment Outcome</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUclOwzAQtRCIVtAP4IJ85JISx0vsCxIqW6VKXMrZShwnMUriYDsg_p50oZS5zOjNzJvlAXCF4jniDCe3tlM2ZK7SYY6w4OgETJEgIkooxadH8QTMvH-PR6Mk5Yk4B5OEx3GSCjEFD8uuGFQwtoO2hL7XypRGwTWsddNrFwmodNN4GCw0XW1yE2DVGNtmWxxWzn6F-hKclVnj9WzvL8Db0-N68RKtXp-Xi_tVpDBlIcKKFWpcVSUMF4qIWLAyiQlCG5SkmchZwTlOdTx6SjljmOQ6p4QJnfOC4Atwt-Pth7zVhdJdcFkje2fazH1Lmxn5P9OZWlb2U1JMCU_ZSHCzJ3D2Y9A-yNb4zSFZp-3gJeIUMYEFScdStCtVznrvdHkYg2K5FUD-CSC3Aow918f7HTp-341_AD8EhCg</recordid><startdate>20170117</startdate><enddate>20170117</enddate><creator>Zheng, Haiyan</creator><creator>Yang, Baohua</creator><creator>Xu, Dedong</creator><creator>Wang, Wenbo</creator><creator>Tan, Jie</creator><creator>Sun, Liyuan</creator><creator>Li, Qinghua</creator><creator>Sun, Li</creator><creator>Xia, Xuewei</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170117</creationdate><title>Induction of specific T helper-9 cells to inhibit glioma cell growth</title><author>Zheng, Haiyan ; Yang, Baohua ; Xu, Dedong ; Wang, Wenbo ; Tan, Jie ; Sun, Liyuan ; Li, Qinghua ; Sun, Li ; Xia, Xuewei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-3c6dc139c263dc49096f20411dc1347a9b6d8837e06d85586634beb5469eb8d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adoptive Transfer - methods</topic><topic>Animals</topic><topic>Antigens, Neoplasm - administration & dosage</topic><topic>Apoptosis</topic><topic>Brain Neoplasms - immunology</topic><topic>Brain Neoplasms - therapy</topic><topic>CD4-Positive T-Lymphocytes - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Combined Modality Therapy</topic><topic>Enterotoxins - administration & dosage</topic><topic>Enterotoxins - pharmacology</topic><topic>Glioma - immunology</topic><topic>Glioma - therapy</topic><topic>Interleukin-9 - metabolism</topic><topic>Male</topic><topic>Mice</topic><topic>Research Paper</topic><topic>T-Lymphocytes, Helper-Inducer - metabolism</topic><topic>Treatment Outcome</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>online_resources</toplevel><creatorcontrib>Zheng, Haiyan</creatorcontrib><creatorcontrib>Yang, Baohua</creatorcontrib><creatorcontrib>Xu, Dedong</creatorcontrib><creatorcontrib>Wang, Wenbo</creatorcontrib><creatorcontrib>Tan, Jie</creatorcontrib><creatorcontrib>Sun, Liyuan</creatorcontrib><creatorcontrib>Li, Qinghua</creatorcontrib><creatorcontrib>Sun, Li</creatorcontrib><creatorcontrib>Xia, Xuewei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zheng, Haiyan</au><au>Yang, Baohua</au><au>Xu, Dedong</au><au>Wang, Wenbo</au><au>Tan, Jie</au><au>Sun, Liyuan</au><au>Li, Qinghua</au><au>Sun, Li</au><au>Xia, Xuewei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Induction of specific T helper-9 cells to inhibit glioma cell growth</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-01-17</date><risdate>2017</risdate><volume>8</volume><issue>3</issue><spage>4864</spage><epage>4874</epage><pages>4864-4874</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>The effects of Staphylococcal enterotoxin B (SEB) on regulation of immune response have been recognized; whether SEB can enhance the effects of immunotherapy on glioma remains to be investigated. This study tests a hypothesis that administration with SEB enhances the effects of specific immunotherapy on glioma growth in mice. In this study, a glioma-bearing mouse model was developed by adoptive transfer with GL261 cells (a mouse glioma cell line). The mice were treated with the GL261 cell extracts (used as an Ag) with or without administration of SEB. We observed that treating glioma-bearing mice with the glioma Ag and SEB induced glioma-specific Th9 cells in both glioma tissue and the spleen. Treating CD4+ CD25- T cells with SEB increased p300 phosphorylation, histone H3K4 acetylation at the interleukin (IL)-9 promoter locus, and increased the IL-9 transcriptional factor binding to the IL-9 promoter. Treating CD4+ CD25- T cells with both SEB and glioma Ag induced glioma-specific Th9 cells. The glioma-specific Th9 cells induced glioma cell apoptosis in the culture. Treating the glioma-bearing mice with SEB and glioma Ag significantly inhibited the glioma growth. In conclusion, SEB plus glioma Ag immunotherapy inhibits the experimental glioma growth, which may be a novel therapeutic remedy for the treatment of glioma.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>28002799</pmid><doi>10.18632/oncotarget.13981</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals; PubMed Central Open Access |
| subjects | Adoptive Transfer - methods Animals Antigens, Neoplasm - administration & dosage Apoptosis Brain Neoplasms - immunology Brain Neoplasms - therapy CD4-Positive T-Lymphocytes - metabolism Cell Line, Tumor Combined Modality Therapy Enterotoxins - administration & dosage Enterotoxins - pharmacology Glioma - immunology Glioma - therapy Interleukin-9 - metabolism Male Mice Research Paper T-Lymphocytes, Helper-Inducer - metabolism Treatment Outcome Xenograft Model Antitumor Assays |
| title | Induction of specific T helper-9 cells to inhibit glioma cell growth |
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