The role of tumor microenvironment in therapeutic resistance
Cancer cells undergo unlimited progression and survival owing to activation of oncogenes. However, support of the tumor microenvironment is essential to the formation of clinically relevant tumors. Recent evidence indicates that the tumor microenvironment is a critical regulator of immune escape, pr...
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| Veröffentlicht in: | Oncotarget 2017-01, Vol.8 (3), p.3933-3945 |
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| creator | Son, Beomseok Lee, Sungmin Youn, HyeSook Kim, EunGi Kim, Wanyeon Youn, BuHyun |
| description | Cancer cells undergo unlimited progression and survival owing to activation of oncogenes. However, support of the tumor microenvironment is essential to the formation of clinically relevant tumors. Recent evidence indicates that the tumor microenvironment is a critical regulator of immune escape, progression, and distant metastasis of cancer. Moreover, the tumor microenvironment is known to be involved in acquired resistance of tumors to various therapies. Despite significant advances in chemotherapy and radiotherapy, occurrence of therapeutic resistance leads to reduced efficacy. This review highlights myeloid cells, cancer-associated fibroblasts, and mesenchymal stem cells consisting of the tumor microenvironment, as well as the relevant signaling pathways that eventually render cancer cells to be therapeutically resistant. |
| doi_str_mv | 10.18632/oncotarget.13907 |
| format | Article |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free E- Journals; PubMed Central Open Access |
| subjects | Drug Resistance, Neoplasm Epithelial-Mesenchymal Transition Gene Expression Regulation, Neoplastic Humans Mesenchymal Stromal Cells - cytology Mesenchymal Stromal Cells - metabolism Myeloid Cells - cytology Myeloid Cells - metabolism Neoplasms - metabolism Radiation Tolerance Research Paper Tumor Microenvironment |
| title | The role of tumor microenvironment in therapeutic resistance |
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