Antagonizing functions of BARD1 and its alternatively spliced variant BARD1δ in telomere stability

Previous reports have shown that expression of BARD1δ, a deletion-bearing isoform of BARD1, correlates with tumor aggressiveness and progression. We show that expression of BARD1δ induces cell cycle arrest in vitro and in vivo in non-malignant cells. We investigated the mechanism that leads to proli...

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Veröffentlicht in:	Oncotarget 2017-02, Vol.8 (6), p.9339-9353
Hauptverfasser:	Pilyugin, Maxim, André, Pierre-Alain, Ratajska, Magdalena, Kuzniacka, Alina, Limon, Janusz, Tournier, Benjamin B, Colas, Julien, Laurent, Geoff, Irminger-Finger, Irmgard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Animals Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Cell Proliferation Chromosomal Instability Female G2 Phase Cell Cycle Checkpoints Gene Expression Regulation, Neoplastic Germ-Line Mutation HEK293 Cells Humans Mice, Inbred C57BL Mice, Transgenic Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Protein Binding Protein Isoforms Research Paper Signal Transduction Telomere - genetics Telomere - metabolism Telomere - pathology Telomere Homeostasis Telomere-Binding Proteins - metabolism Telomeric Repeat Binding Protein 2 - metabolism Time Factors Transfection Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Up-Regulation
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