Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors

Quorum sensing is a process of cell-cell communication that bacteria use to regulate collective behaviors. Quorum sensing depends on the production, detection, and group-wide response to extracellular signal molecules called autoinducers. In many bacterial species, quorum sensing controls virulence...

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Veröffentlicht in:	The Journal of biological chemistry 2017-03, Vol.292 (10), p.4064-4076
Hauptverfasser:	Paczkowski, Jon E., Mukherjee, Sampriti, McCready, Amelia R., Cong, Jian-Ping, Aquino, Christopher J., Kim, Hahn, Henke, Brad R., Smith, Chari D., Bassler, Bonnie L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Bacterial Proteins - antagonists & inhibitors Biofilms - drug effects Biofilms - growth & development flavonoid Flavonoids - pharmacology inhibition mechanism Microbiology Pseudomonas Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - growth & development quorum sensing Quorum Sensing - drug effects Quorum Sensing - physiology Small Molecule Libraries - pharmacology Structure-Activity Relationship Trans-Activators - antagonists & inhibitors Virulence - drug effects virulence factor
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