BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage
Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the e...
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| Veröffentlicht in: | Oxidative medicine and cellular longevity 2017-01, Vol.2017 (2017), p.1-10 |
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| creator | Tang, Bei-sha Tan, Li-ming Wang, Chun-yu Shen, Xiang-min Jiang, Bo Tang, Jian-guang Lu, Jia-Hong Rizwana, Kousar Zhang, Hai-nan Tan, Jieqiong Qin, Li-xia Guo, Ji-feng |
| description | Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1. |
| doi_str_mv | 10.1155/2017/5094934 |
| format | Article |
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DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2017/5094934</identifier><identifier>PMID: 28348719</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adaptor Proteins, Signal Transducing - antagonists & inhibitors ; Adaptor Proteins, Signal Transducing - genetics ; Adaptor Proteins, Signal Transducing - metabolism ; Apoptosis ; Apoptosis - drug effects ; Cell death ; Cellular signal transduction ; Gene mutations ; Genes ; Genetic aspects ; HEK293 Cells ; Homeostasis ; HSP70 Heat-Shock Proteins - antagonists & inhibitors ; HSP70 Heat-Shock Proteins - genetics ; HSP70 Heat-Shock Proteins - metabolism ; Humans ; Immunoglobulins ; Immunoprecipitation ; Laboratories ; Membrane Potential, Mitochondrial - drug effects ; Microscopy, Fluorescence ; Mitochondria ; Mitochondria - metabolism ; Mutation ; Neurodegeneration ; Neuroprotective Agents - metabolism ; Oxidative Stress ; Parkinson's disease ; Pathogenesis ; Plasmids ; Protein Deglycase DJ-1 - genetics ; Protein Deglycase DJ-1 - metabolism ; Proteins ; Reactive Oxygen Species - metabolism ; RNA Interference ; RNA, Small Interfering - metabolism ; Rotenone - pharmacology ; Science</subject><ispartof>Oxidative medicine and cellular longevity, 2017-01, Vol.2017 (2017), p.1-10</ispartof><rights>Copyright © 2017 Li-xia Qin et al.</rights><rights>COPYRIGHT 2017 John Wiley & Sons, Inc.</rights><rights>Copyright © 2017 Li-xia Qin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><rights>Copyright © 2017 Li-xia Qin et al. 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-b381f0bd4c12126d0c0e5b76b18721c9f174d3d66696afa0b2aa46940893a0203</citedby><cites>FETCH-LOGICAL-c499t-b381f0bd4c12126d0c0e5b76b18721c9f174d3d66696afa0b2aa46940893a0203</cites><orcidid>0000-0003-1629-0885 ; 0000-0002-3050-3181</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352890/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352890/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28348719$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Hrelia, Silvana</contributor><creatorcontrib>Tang, Bei-sha</creatorcontrib><creatorcontrib>Tan, Li-ming</creatorcontrib><creatorcontrib>Wang, Chun-yu</creatorcontrib><creatorcontrib>Shen, Xiang-min</creatorcontrib><creatorcontrib>Jiang, Bo</creatorcontrib><creatorcontrib>Tang, Jian-guang</creatorcontrib><creatorcontrib>Lu, Jia-Hong</creatorcontrib><creatorcontrib>Rizwana, Kousar</creatorcontrib><creatorcontrib>Zhang, Hai-nan</creatorcontrib><creatorcontrib>Tan, Jieqiong</creatorcontrib><creatorcontrib>Qin, Li-xia</creatorcontrib><creatorcontrib>Guo, Ji-feng</creatorcontrib><title>BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage</title><title>Oxidative medicine and cellular longevity</title><addtitle>Oxid Med Cell Longev</addtitle><description>Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</description><subject>Adaptor Proteins, Signal Transducing - antagonists & inhibitors</subject><subject>Adaptor Proteins, Signal Transducing - genetics</subject><subject>Adaptor Proteins, Signal Transducing - metabolism</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Cell death</subject><subject>Cellular signal transduction</subject><subject>Gene mutations</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>HEK293 Cells</subject><subject>Homeostasis</subject><subject>HSP70 Heat-Shock Proteins - antagonists & inhibitors</subject><subject>HSP70 Heat-Shock Proteins - genetics</subject><subject>HSP70 Heat-Shock Proteins - metabolism</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Immunoprecipitation</subject><subject>Laboratories</subject><subject>Membrane Potential, Mitochondrial - drug effects</subject><subject>Microscopy, Fluorescence</subject><subject>Mitochondria</subject><subject>Mitochondria - metabolism</subject><subject>Mutation</subject><subject>Neurodegeneration</subject><subject>Neuroprotective Agents - metabolism</subject><subject>Oxidative Stress</subject><subject>Parkinson's disease</subject><subject>Pathogenesis</subject><subject>Plasmids</subject><subject>Protein Deglycase DJ-1 - genetics</subject><subject>Protein Deglycase DJ-1 - metabolism</subject><subject>Proteins</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>RNA Interference</subject><subject>RNA, Small Interfering - metabolism</subject><subject>Rotenone - pharmacology</subject><subject>Science</subject><issn>1942-0900</issn><issn>1942-0994</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNks1v1DAQxSNERUvhxhlF4oIEoR7HduwL0rL9oKjQC5ytieNsXGXjreO08N_jsMsWOHHyaOb3nj16zrIXQN4BcH5CCVQnnCimSvYoOwLFaEGUYo_3NSGH2dNxvCFElJTBk-yQypLJCtRRFj4sLnh-OUQb0MQxv3exy08_FZDj0KR-52qX2rGz-Rc7Bb8JPloT3Z3Nz9rWzhLfbgXR50u_rjHmn130pvNDExz2-fV31-AvxSmucWWfZQct9qN9vjuPs2_nZ1-XH4ur64vL5eKqMEypWNSlhJbUDTNAgYqGGGJ5XYkaZEXBqBYq1pSNEEIJbJHUFJEJxYhUJRJKyuPs_dZ3M9Vr2xg7xIC93gS3xvBDe3T678ngOr3yd5qXnEo1G7zeGQR_O9kx6rUbje17HKyfRg1SQlUBB5nQV_-gN34KQ1ovUZVggnHGHqgV9la7ofXpXjOb6gXnXHIigCbq7ZYywY9jsO3-yUD0HLmeI9e7yBP-8s819_DvjBPwZgt0bmjw3v2nnU2MbfGBTr9JSlb-BPX9usM</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Tang, Bei-sha</creator><creator>Tan, Li-ming</creator><creator>Wang, Chun-yu</creator><creator>Shen, Xiang-min</creator><creator>Jiang, Bo</creator><creator>Tang, Jian-guang</creator><creator>Lu, Jia-Hong</creator><creator>Rizwana, Kousar</creator><creator>Zhang, Hai-nan</creator><creator>Tan, Jieqiong</creator><creator>Qin, Li-xia</creator><creator>Guo, Ji-feng</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1629-0885</orcidid><orcidid>https://orcid.org/0000-0002-3050-3181</orcidid></search><sort><creationdate>20170101</creationdate><title>BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage</title><author>Tang, Bei-sha ; Tan, Li-ming ; Wang, Chun-yu ; Shen, Xiang-min ; Jiang, Bo ; Tang, Jian-guang ; Lu, Jia-Hong ; Rizwana, Kousar ; Zhang, Hai-nan ; Tan, Jieqiong ; Qin, Li-xia ; Guo, Ji-feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-b381f0bd4c12126d0c0e5b76b18721c9f174d3d66696afa0b2aa46940893a0203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adaptor Proteins, Signal Transducing - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oxidative medicine and cellular longevity</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Bei-sha</au><au>Tan, Li-ming</au><au>Wang, Chun-yu</au><au>Shen, Xiang-min</au><au>Jiang, Bo</au><au>Tang, Jian-guang</au><au>Lu, Jia-Hong</au><au>Rizwana, Kousar</au><au>Zhang, Hai-nan</au><au>Tan, Jieqiong</au><au>Qin, Li-xia</au><au>Guo, Ji-feng</au><au>Hrelia, Silvana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage</atitle><jtitle>Oxidative medicine and cellular longevity</jtitle><addtitle>Oxid Med Cell Longev</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>2017</volume><issue>2017</issue><spage>1</spage><epage>10</epage><pages>1-10</pages><issn>1942-0900</issn><eissn>1942-0994</eissn><abstract>Loss-of-function mutations in gene encoding DJ-1 contribute to the pathogenesis of autosomal recessive early-onset familial forms of Parkinson’s disease (PD). DJ-1 is a multifunctional protein and plays a protective role against oxidative stress-induced mitochondrial damage and cell death, but the exact mechanism underlying this is not yet clearly understood. Here, using coimmunoprecipitation (Co-IP) and immunofluorescence methods, we prove that Bcl-2-associated athanogene 5 (BAG5), a BAG family member, interacts with DJ-1 in mammalian cells. Moreover, we show that BAG5 could decrease stability of DJ-1 and weaken its role in mitochondrial protection probably by influencing dimerization in stress condition. Our study reveals the relationship of BAG5 and DJ-1 suggesting a potential role for BAG5 in the pathogenesis of PD through its functional interactions with DJ-1.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>28348719</pmid><doi>10.1155/2017/5094934</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1629-0885</orcidid><orcidid>https://orcid.org/0000-0002-3050-3181</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adaptor Proteins, Signal Transducing - antagonists & inhibitors Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Apoptosis Apoptosis - drug effects Cell death Cellular signal transduction Gene mutations Genes Genetic aspects HEK293 Cells Homeostasis HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Humans Immunoglobulins Immunoprecipitation Laboratories Membrane Potential, Mitochondrial - drug effects Microscopy, Fluorescence Mitochondria Mitochondria - metabolism Mutation Neurodegeneration Neuroprotective Agents - metabolism Oxidative Stress Parkinson's disease Pathogenesis Plasmids Protein Deglycase DJ-1 - genetics Protein Deglycase DJ-1 - metabolism Proteins Reactive Oxygen Species - metabolism RNA Interference RNA, Small Interfering - metabolism Rotenone - pharmacology Science |
| title | BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage |
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