Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation
Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this r...
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| Veröffentlicht in: | Frontiers in cellular neuroscience 2017-03, Vol.11, p.76-76 |
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| creator | Alia, Claudia Spalletti, Cristina Lai, Stefano Panarese, Alessandro Lamola, Giuseppe Bertolucci, Federica Vallone, Fabio Di Garbo, Angelo Chisari, Carmelo Micera, Silvestro Caleo, Matteo |
| description | Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration. |
| doi_str_mv | 10.3389/fncel.2017.00076 |
| format | Article |
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A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration.</description><identifier>ISSN: 1662-5102</identifier><identifier>EISSN: 1662-5102</identifier><identifier>DOI: 10.3389/fncel.2017.00076</identifier><identifier>PMID: 28360842</identifier><language>eng</language><publisher>Switzerland: Frontiers Research Foundation</publisher><subject>Animal models ; Brain injury ; Brain research ; Cortex (motor) ; Fitness equipment ; Functional plasticity ; Ischemia ; Laboratories ; Neural networks ; Neurology ; Neuroscience ; Neurosciences ; Rehabilitation ; Stroke ; Studies ; Training</subject><ispartof>Frontiers in cellular neuroscience, 2017-03, Vol.11, p.76-76</ispartof><rights>2017. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright © 2017 Alia, Spalletti, Lai, Panarese, Lamola, Bertolucci, Vallone, Di Garbo, Chisari, Micera and Caleo. 2017 Alia, Spalletti, Lai, Panarese, Lamola, Bertolucci, Vallone, Di Garbo, Chisari, Micera and Caleo</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c424t-6ab1447610f54469ba55731b16339fff69ddf34b289525a8c06d6de2d197bb5c3</citedby><cites>FETCH-LOGICAL-c424t-6ab1447610f54469ba55731b16339fff69ddf34b289525a8c06d6de2d197bb5c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352696/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5352696/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27903,27904,53768,53770</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28360842$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Alia, Claudia</creatorcontrib><creatorcontrib>Spalletti, Cristina</creatorcontrib><creatorcontrib>Lai, Stefano</creatorcontrib><creatorcontrib>Panarese, Alessandro</creatorcontrib><creatorcontrib>Lamola, Giuseppe</creatorcontrib><creatorcontrib>Bertolucci, Federica</creatorcontrib><creatorcontrib>Vallone, Fabio</creatorcontrib><creatorcontrib>Di Garbo, Angelo</creatorcontrib><creatorcontrib>Chisari, Carmelo</creatorcontrib><creatorcontrib>Micera, Silvestro</creatorcontrib><creatorcontrib>Caleo, Matteo</creatorcontrib><title>Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation</title><title>Frontiers in cellular neuroscience</title><addtitle>Front Cell Neurosci</addtitle><description>Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. A better understanding of this plastic remodeling is crucial to develop more effective strategies for stroke rehabilitation. In this review article, we discuss advances in the comprehension of post-stroke network reorganization in patients and animal models. We first focus on rodent studies that have shed light on the mechanisms underlying neuronal remodeling in the perilesional area and contralesional hemisphere after motor cortex infarcts. Analysis of electrophysiological data has demonstrated brain-wide alterations in functional connectivity in both hemispheres, well beyond the infarcted area. We then illustrate the potential use of non-invasive brain stimulation (NIBS) techniques to boost recovery. We finally discuss rehabilitative protocols based on robotic devices as a tool to promote endogenous plasticity and functional restoration.</description><subject>Animal models</subject><subject>Brain injury</subject><subject>Brain research</subject><subject>Cortex (motor)</subject><subject>Fitness equipment</subject><subject>Functional plasticity</subject><subject>Ischemia</subject><subject>Laboratories</subject><subject>Neural networks</subject><subject>Neurology</subject><subject>Neuroscience</subject><subject>Neurosciences</subject><subject>Rehabilitation</subject><subject>Stroke</subject><subject>Studies</subject><subject>Training</subject><issn>1662-5102</issn><issn>1662-5102</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNpdkctvFSEYxYmxsQ_duzIkbtzcW17DgAuTemO1SVMTH2sCDHOHOhemwNR01z9d7m1t2q4-Es45nI8fAG8xWlIq5HEfrBuXBOF2iRBq-QtwgDkniwYj8vLReR8c5nyJECeciVdgnwjKkWDkANxeuDnFadS5eAtXgw5rl-FpHMf414c1_Jy0D_As28FtvIY6dLAMzie4iqEkb-biY4Alwp8lxT8O_nA2Xrt08xFe1DnCk2lKUVd3hjVn91hygzZ-9EVvva_BXq_H7N7czyPw-_TLr9W3xfn3r2erk_OFZYSVBdcGM9ZyjPqGMS6NbpqWYoM5pbLvey67rqfMECEb0mhhEe9450iHZWtMY-kR-HSXO81m4zrran09qin5jU43Kmqvnt4EP6h1vFYNbQiXvAZ8uA9I8Wp2uaiNz_X7Rx1cnLPCQlBcC0pSpe-fSS_jnEJdTxEisGQtk7Kq0J3Kpphzcv1DGYzUFq_a4VVbvGqHt1rePV7iwfCfJ_0HJROkTQ</recordid><startdate>20170316</startdate><enddate>20170316</enddate><creator>Alia, Claudia</creator><creator>Spalletti, Cristina</creator><creator>Lai, Stefano</creator><creator>Panarese, Alessandro</creator><creator>Lamola, Giuseppe</creator><creator>Bertolucci, Federica</creator><creator>Vallone, Fabio</creator><creator>Di Garbo, Angelo</creator><creator>Chisari, Carmelo</creator><creator>Micera, Silvestro</creator><creator>Caleo, Matteo</creator><general>Frontiers Research Foundation</general><general>Frontiers Media S.A</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170316</creationdate><title>Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation</title><author>Alia, Claudia ; Spalletti, Cristina ; Lai, Stefano ; Panarese, Alessandro ; Lamola, Giuseppe ; Bertolucci, Federica ; Vallone, Fabio ; Di Garbo, Angelo ; Chisari, Carmelo ; Micera, Silvestro ; Caleo, Matteo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-6ab1447610f54469ba55731b16339fff69ddf34b289525a8c06d6de2d197bb5c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animal models</topic><topic>Brain injury</topic><topic>Brain research</topic><topic>Cortex (motor)</topic><topic>Fitness equipment</topic><topic>Functional plasticity</topic><topic>Ischemia</topic><topic>Laboratories</topic><topic>Neural networks</topic><topic>Neurology</topic><topic>Neuroscience</topic><topic>Neurosciences</topic><topic>Rehabilitation</topic><topic>Stroke</topic><topic>Studies</topic><topic>Training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Alia, Claudia</creatorcontrib><creatorcontrib>Spalletti, Cristina</creatorcontrib><creatorcontrib>Lai, Stefano</creatorcontrib><creatorcontrib>Panarese, Alessandro</creatorcontrib><creatorcontrib>Lamola, Giuseppe</creatorcontrib><creatorcontrib>Bertolucci, Federica</creatorcontrib><creatorcontrib>Vallone, Fabio</creatorcontrib><creatorcontrib>Di Garbo, Angelo</creatorcontrib><creatorcontrib>Chisari, Carmelo</creatorcontrib><creatorcontrib>Micera, Silvestro</creatorcontrib><creatorcontrib>Caleo, Matteo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Frontiers in cellular neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Alia, Claudia</au><au>Spalletti, Cristina</au><au>Lai, Stefano</au><au>Panarese, Alessandro</au><au>Lamola, Giuseppe</au><au>Bertolucci, Federica</au><au>Vallone, Fabio</au><au>Di Garbo, Angelo</au><au>Chisari, Carmelo</au><au>Micera, Silvestro</au><au>Caleo, Matteo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation</atitle><jtitle>Frontiers in cellular neuroscience</jtitle><addtitle>Front Cell Neurosci</addtitle><date>2017-03-16</date><risdate>2017</risdate><volume>11</volume><spage>76</spage><epage>76</epage><pages>76-76</pages><issn>1662-5102</issn><eissn>1662-5102</eissn><abstract>Ischemic damage to the brain triggers substantial reorganization of spared areas and pathways, which is associated with limited, spontaneous restoration of function. 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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; PubMed Central Open Access |
| subjects | Animal models Brain injury Brain research Cortex (motor) Fitness equipment Functional plasticity Ischemia Laboratories Neural networks Neurology Neuroscience Neurosciences Rehabilitation Stroke Studies Training |
| title | Neuroplastic Changes Following Brain Ischemia and their Contribution to Stroke Recovery: Novel Approaches in Neurorehabilitation |
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