Constitutive NOS uncoupling and NADPH oxidase upregulation in the penis of type 2 diabetic men with erectile dysfunction

Summary Erectile dysfunction (ED) associated with type 2 diabetes mellitus (T2DM) involves dysfunctional nitric oxide (NO) signaling and increased oxidative stress in the penis. However, the mechanisms of endothelial NO synthase (eNOS) and neuronal NO synthase (nNOS) dysregulation, and the sources o...

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Veröffentlicht in:	Andrology (Oxford) 2017-03, Vol.5 (2), p.294-298
Hauptverfasser:	Musicki, B., Burnett, A. L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - metabolism eNOS uncoupling Erectile Dysfunction - etiology Erectile Dysfunction - metabolism human Humans Male Middle Aged NADPH Oxidases - metabolism Nitric Oxide Synthase - metabolism nNOS uncoupling oxidative stress Oxidative Stress - physiology Penis - metabolism Reactive Oxygen Species - metabolism Signal Transduction - physiology Up-Regulation - physiology
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