T lymphocyte SHP2-deficiency triggers anti-tumor immunity to inhibit colitis-associated cancer in mice

Nonresolving inflammation is involved in the initiation and progression process of tumorigenesis. Src homology 2 domain-containing tyrosine phosphatase 2 (SHP2) is known to inhibit acute inflammation but its role in chronic inflammation-associated cancer remains unclear. The role of SHP2 in T cells...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (5), p.7586-7597
Hauptverfasser:	Liu, Wen, Guo, Wenjie, Shen, Lihong, Chen, Zhen, Luo, Qiong, Luo, Xiaolin, Feng, GenSheng, Shu, Yongqian, Gu, Yanhong, Xu, Qiang, Sun, Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Azoxymethane CD4-Positive T-Lymphocytes - enzymology CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology Cells, Cultured Colitis - chemically induced Colitis - enzymology Colitis - immunology Colonic Neoplasms - chemically induced Colonic Neoplasms - enzymology Colonic Neoplasms - immunology Colonic Neoplasms - prevention & control Cytotoxicity, Immunologic Dextran Sulfate Disease Models, Animal Fas Ligand Protein - metabolism Granzymes - metabolism Inflammation Mediators - immunology Inflammation Mediators - metabolism Interferon-gamma - genetics Interferon-gamma - metabolism Lymphocytes, Tumor-Infiltrating - enzymology Lymphocytes, Tumor-Infiltrating - immunology Mice, Knockout Perforin - metabolism Phosphorylation Protein Tyrosine Phosphatase, Non-Receptor Type 11 - deficiency Protein Tyrosine Phosphatase, Non-Receptor Type 11 - genetics Research Paper Signal Transduction STAT1 Transcription Factor - metabolism Time Factors Tumor Microenvironment
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