Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma

Epithelial-Mesenchymal Transition (EMT) is a critical step in the progression of cancer. Malignant melanoma, a cancer developed from pigmented melanocytes, metastasizes through an EMT-like process. Ten-eleven translocation (TET) enzymes, catalyzing the conversion of 5-methylcytosine (5mC) to 5-hydro...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (1), p.315-328
Hauptverfasser:	Gong, Fuxing, Guo, Yu, Niu, Yiqian, Jin, Jiawei, Zhang, Xiaojuan, Shi, Xiaoqian, Zhang, Limeng, Li, Runting, Chen, Longxin, Ma, Runlin Z
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine - analogs & derivatives 5-Methylcytosine - metabolism Animals Azacitidine - analogs & derivatives Azacitidine - pharmacology Cell Line, Tumor Chromatin Immunoprecipitation Dioxygenases - genetics Dioxygenases - metabolism Disease Progression DNA (Cytosine-5-)-Methyltransferases - metabolism DNA Demethylation - drug effects DNA Methylation - drug effects DNA Methylation - genetics DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Down-Regulation Epigenesis, Genetic Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation, Neoplastic Gene Knockdown Techniques Humans Male Melanoma - genetics Melanoma - pathology Mice Mice, Inbred C57BL Microscopy, Fluorescence Promoter Regions, Genetic Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Research Paper RNA, Small Interfering - metabolism Transforming Growth Factor beta1 - metabolism Xenograft Model Antitumor Assays
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