DNA methylation signature (SAM40) identifies subgroups of the Luminal A breast cancer samples with distinct survival

Breast cancer patients with Luminal A disease generally have a good prognosis, but among this patient group are patients with good prognosis that are currently overtreated with adjuvant chemotherapy, and also patients that have a bad prognosis and should be given more aggressive treatment. There is...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (1), p.1074-1082
Hauptverfasser:	Fleischer, Thomas, Klajic, Jovana, Aure, Miriam Ragle, Louhimo, Riku, Pladsen, Arne V, Ottestad, Lars, Touleimat, Nizar, Laakso, Marko, Halvorsen, Ann Rita, Grenaker Alnæs, Grethe I, Riis, Margit L H, Helland, Åslaug, Hautaniemi, Sampsa, Lønning, Per Eystein, Naume, Bjørn, Børresen-Dale, Anne-Lise, Tost, Jörg, Kristensen, Vessela N
Format:	Artikel
Sprache:	eng
Schlagworte:	Applications Biochemistry, Molecular Biology Biomarkers, Tumor Breast Neoplasms - genetics Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cellular Biology Cluster Analysis DNA Methylation Epigenesis, Genetic Epigenomics - methods Female Gene Dosage Gene Expression Profiling Gene Expression Regulation, Neoplastic Genetics Human health and pathology Humans Kaplan-Meier Estimate Life Sciences Machine Learning Prognosis Quantitative Methods Research Paper Statistics Transcriptome
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