mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27

Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remai...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (4), p.6304-6318
Hauptverfasser:	Feng, Zhuoying, Zhang, Luping, Zhou, Junchen, Zhou, Shuai, Li, Li, Guo, Xuyan, Feng, Guoying, Ma, Ze, Huang, Wenhua, Huang, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - enzymology Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glioblastoma - drug therapy Glioblastoma - enzymology Glioblastoma - genetics Glioblastoma - pathology Humans Male Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Naphthoquinones - pharmacology Neoplasm Invasiveness Research Paper Signal Transduction - drug effects Time Factors Transfection Tumor Burden - drug effects Xenograft Model Antitumor Assays
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