mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27
Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remai...
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| Veröffentlicht in: | Oncotarget 2017-01, Vol.8 (4), p.6304-6318 |
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| creator | Feng, Zhuoying Zhang, Luping Zhou, Junchen Zhou, Shuai Li, Li Guo, Xuyan Feng, Guoying Ma, Ze Huang, Wenhua Huang, Fei |
| description | Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remain unknown, especially the latter. The objective of this study was to further investigate the role of mir-218-2 in glioma. Our results indicated that mir-218-2 is highly overexpressed in glioma. Furthermore, we showed that mir-218-2 is positively correlated with the growth, invasion, migration, and drug susceptibility (to β-lapachone) of glioma cells. In vitro, the overexpression of mir-218-2 promoted glioma cell proliferation, invasion, and migration. In addition, the overexpression of mir-218-2 in vivo was found to increase glioma tumor growth. Accordingly, the inhibition of mir-218-2 resulted in the opposite effects. Cell division cycle 27 (CDC27), the downstream target of mir-218-2, is involved in the regulation of glioma cells. Our results indicate that the overexpression of CDC27 counteracted the function of mir-218-2 in glioma cells. These novel findings provide new insight in the application of mir-218-2 as a potential glioma treatment. |
| doi_str_mv | 10.18632/oncotarget.13850 |
| format | Article |
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Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remain unknown, especially the latter. The objective of this study was to further investigate the role of mir-218-2 in glioma. Our results indicated that mir-218-2 is highly overexpressed in glioma. Furthermore, we showed that mir-218-2 is positively correlated with the growth, invasion, migration, and drug susceptibility (to β-lapachone) of glioma cells. In vitro, the overexpression of mir-218-2 promoted glioma cell proliferation, invasion, and migration. In addition, the overexpression of mir-218-2 in vivo was found to increase glioma tumor growth. Accordingly, the inhibition of mir-218-2 resulted in the opposite effects. Cell division cycle 27 (CDC27), the downstream target of mir-218-2, is involved in the regulation of glioma cells. Our results indicate that the overexpression of CDC27 counteracted the function of mir-218-2 in glioma cells. These novel findings provide new insight in the application of mir-218-2 as a potential glioma treatment.</description><identifier>ISSN: 1949-2553</identifier><identifier>EISSN: 1949-2553</identifier><identifier>DOI: 10.18632/oncotarget.13850</identifier><identifier>PMID: 27974673</identifier><language>eng</language><publisher>United States: Impact Journals LLC</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics ; Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism ; Brain Neoplasms - drug therapy ; Brain Neoplasms - enzymology ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Cell Line, Tumor ; Cell Movement - drug effects ; Cell Proliferation - drug effects ; Drug Resistance, Neoplasm - genetics ; Gene Expression Regulation, Enzymologic ; Gene Expression Regulation, Neoplastic ; Glioblastoma - drug therapy ; Glioblastoma - enzymology ; Glioblastoma - genetics ; Glioblastoma - pathology ; Humans ; Male ; Mice, Inbred BALB C ; Mice, Nude ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Naphthoquinones - pharmacology ; Neoplasm Invasiveness ; Research Paper ; Signal Transduction - drug effects ; Time Factors ; Transfection ; Tumor Burden - drug effects ; Xenograft Model Antitumor Assays</subject><ispartof>Oncotarget, 2017-01, Vol.8 (4), p.6304-6318</ispartof><rights>Copyright: © 2017 Feng et al. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-b31adb18b8708f07bbb383712b4476512df11064737ba5cd2dac156843c5f2643</citedby><cites>FETCH-LOGICAL-c356t-b31adb18b8708f07bbb383712b4476512df11064737ba5cd2dac156843c5f2643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351633/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5351633/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27974673$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Feng, Zhuoying</creatorcontrib><creatorcontrib>Zhang, Luping</creatorcontrib><creatorcontrib>Zhou, Junchen</creatorcontrib><creatorcontrib>Zhou, Shuai</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Guo, Xuyan</creatorcontrib><creatorcontrib>Feng, Guoying</creatorcontrib><creatorcontrib>Ma, Ze</creatorcontrib><creatorcontrib>Huang, Wenhua</creatorcontrib><creatorcontrib>Huang, Fei</creatorcontrib><title>mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27</title><title>Oncotarget</title><addtitle>Oncotarget</addtitle><description>Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. 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These novel findings provide new insight in the application of mir-218-2 as a potential glioma treatment.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics</subject><subject>Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism</subject><subject>Brain Neoplasms - drug therapy</subject><subject>Brain Neoplasms - enzymology</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Cell Line, Tumor</subject><subject>Cell Movement - drug effects</subject><subject>Cell Proliferation - drug effects</subject><subject>Drug Resistance, Neoplasm - genetics</subject><subject>Gene Expression Regulation, Enzymologic</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Glioblastoma - drug therapy</subject><subject>Glioblastoma - enzymology</subject><subject>Glioblastoma - genetics</subject><subject>Glioblastoma - pathology</subject><subject>Humans</subject><subject>Male</subject><subject>Mice, Inbred BALB C</subject><subject>Mice, Nude</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Naphthoquinones - pharmacology</subject><subject>Neoplasm Invasiveness</subject><subject>Research Paper</subject><subject>Signal Transduction - drug effects</subject><subject>Time Factors</subject><subject>Transfection</subject><subject>Tumor Burden - drug effects</subject><subject>Xenograft Model Antitumor Assays</subject><issn>1949-2553</issn><issn>1949-2553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVUU1LxDAQDaKo6P4AL5KjB6tN0nz0Isj6CYIXBW8hSdNupE3WJFX895bd9WsuM8O89-bBA-AIlWdIMILPgzchq9jZfIaIoOUW2Ed1VReYUrL9Z94Ds5Rey6loxQWud8Ee5jWvGCf74GVwscBIFBguYxhCtgl2vQu6VymHQU1bDB95cQqdf1fJBQ-Vb2ATxw5Gm1zKyhsL9SdcW3G-g_OrOeaHYKdVfbKzTT8AzzfXT_O74uHx9n5--VAYQlkuNEGq0UhowUvRllxrTQThCOuq4owi3LQIlazihGtFTYMbZRBloiKGtphV5ABcrHWXox5sY6zPUfVyGd2g4qcMysn_F-8WsgvvkhKKGCGTwMlGIIa30aYsB5eM7XvlbRiTRIJiJqjA5QRFa6iJIaVo2583qJSrUORvKHIVysQ5_uvvh_EdAfkC14WLEA</recordid><startdate>20170124</startdate><enddate>20170124</enddate><creator>Feng, Zhuoying</creator><creator>Zhang, Luping</creator><creator>Zhou, Junchen</creator><creator>Zhou, Shuai</creator><creator>Li, Li</creator><creator>Guo, Xuyan</creator><creator>Feng, Guoying</creator><creator>Ma, Ze</creator><creator>Huang, Wenhua</creator><creator>Huang, Fei</creator><general>Impact Journals LLC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170124</creationdate><title>mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27</title><author>Feng, Zhuoying ; Zhang, Luping ; Zhou, Junchen ; Zhou, Shuai ; Li, Li ; Guo, Xuyan ; Feng, Guoying ; Ma, Ze ; Huang, Wenhua ; Huang, Fei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-b31adb18b8708f07bbb383712b4476512df11064737ba5cd2dac156843c5f2643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics</topic><topic>Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism</topic><topic>Brain Neoplasms - drug therapy</topic><topic>Brain Neoplasms - enzymology</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Cell Line, Tumor</topic><topic>Cell Movement - drug effects</topic><topic>Cell Proliferation - drug effects</topic><topic>Drug Resistance, Neoplasm - genetics</topic><topic>Gene Expression Regulation, Enzymologic</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Glioblastoma - drug therapy</topic><topic>Glioblastoma - enzymology</topic><topic>Glioblastoma - genetics</topic><topic>Glioblastoma - pathology</topic><topic>Humans</topic><topic>Male</topic><topic>Mice, Inbred BALB C</topic><topic>Mice, Nude</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Naphthoquinones - pharmacology</topic><topic>Neoplasm Invasiveness</topic><topic>Research Paper</topic><topic>Signal Transduction - drug effects</topic><topic>Time Factors</topic><topic>Transfection</topic><topic>Tumor Burden - drug effects</topic><topic>Xenograft Model Antitumor Assays</topic><toplevel>online_resources</toplevel><creatorcontrib>Feng, Zhuoying</creatorcontrib><creatorcontrib>Zhang, Luping</creatorcontrib><creatorcontrib>Zhou, Junchen</creatorcontrib><creatorcontrib>Zhou, Shuai</creatorcontrib><creatorcontrib>Li, Li</creatorcontrib><creatorcontrib>Guo, Xuyan</creatorcontrib><creatorcontrib>Feng, Guoying</creatorcontrib><creatorcontrib>Ma, Ze</creatorcontrib><creatorcontrib>Huang, Wenhua</creatorcontrib><creatorcontrib>Huang, Fei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncotarget</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Feng, Zhuoying</au><au>Zhang, Luping</au><au>Zhou, Junchen</au><au>Zhou, Shuai</au><au>Li, Li</au><au>Guo, Xuyan</au><au>Feng, Guoying</au><au>Ma, Ze</au><au>Huang, Wenhua</au><au>Huang, Fei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27</atitle><jtitle>Oncotarget</jtitle><addtitle>Oncotarget</addtitle><date>2017-01-24</date><risdate>2017</risdate><volume>8</volume><issue>4</issue><spage>6304</spage><epage>6318</epage><pages>6304-6318</pages><issn>1949-2553</issn><eissn>1949-2553</eissn><abstract>Glioma has become a significant global health problem with substantial morbidity and mortality, underscoring the importance of elucidating its underlying molecular mechanisms. Recent studies have identified mir-218 as an anti-oncogene; however, the specific functions of mir-218-1 and mir-218-2 remain unknown, especially the latter. The objective of this study was to further investigate the role of mir-218-2 in glioma. Our results indicated that mir-218-2 is highly overexpressed in glioma. Furthermore, we showed that mir-218-2 is positively correlated with the growth, invasion, migration, and drug susceptibility (to β-lapachone) of glioma cells. In vitro, the overexpression of mir-218-2 promoted glioma cell proliferation, invasion, and migration. In addition, the overexpression of mir-218-2 in vivo was found to increase glioma tumor growth. Accordingly, the inhibition of mir-218-2 resulted in the opposite effects. Cell division cycle 27 (CDC27), the downstream target of mir-218-2, is involved in the regulation of glioma cells. Our results indicate that the overexpression of CDC27 counteracted the function of mir-218-2 in glioma cells. These novel findings provide new insight in the application of mir-218-2 as a potential glioma treatment.</abstract><cop>United States</cop><pub>Impact Journals LLC</pub><pmid>27974673</pmid><doi>10.18632/oncotarget.13850</doi><tpages>15</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Antineoplastic Agents - pharmacology Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - genetics Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome - metabolism Brain Neoplasms - drug therapy Brain Neoplasms - enzymology Brain Neoplasms - genetics Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Drug Resistance, Neoplasm - genetics Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Glioblastoma - drug therapy Glioblastoma - enzymology Glioblastoma - genetics Glioblastoma - pathology Humans Male Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Naphthoquinones - pharmacology Neoplasm Invasiveness Research Paper Signal Transduction - drug effects Time Factors Transfection Tumor Burden - drug effects Xenograft Model Antitumor Assays |
| title | mir-218-2 promotes glioblastomas growth, invasion and drug resistance by targeting CDC27 |
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