PTEN mediates the cross talk between breast and glial cells in brain metastases leading to rapid disease progression

Despite improvement of therapeutic treatments for breast cancer, the development of brain metastases has become a major limitation to life expectancy for many patients. Brain metastases show very commonly alterations in EGFR and HER2 driven pathways, of which PTEN is an important regulator. Here, we...

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Veröffentlicht in:	Oncotarget 2017-01, Vol.8 (4), p.6155-6168
Hauptverfasser:	Hohensee, Ina, Chuang, Han-Ning, Grottke, Astrid, Werner, Stefan, Schulte, Alexander, Horn, Stefan, Lamszus, Katrin, Bartkowiak, Kai, Witzel, Isabell, Westphal, Manfred, Matschke, Jakob, Glatzel, Markus, Jücker, Manfred, Pukrop, Tobias, Pantel, Klaus, Wikman, Harriet
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain Neoplasms - metabolism Brain Neoplasms - secondary Brain Neoplasms - surgery Cell Line, Tumor Cell Movement Cell Proliferation Coculture Techniques Disease Progression Feedback, Physiological Female Gene Expression Regulation, Neoplastic Humans Neoplasm Invasiveness Neuroglia - metabolism Proto-Oncogene Proteins c-akt - metabolism PTEN Phosphohydrolase - metabolism Research Paper Survival Analysis Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - surgery
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