The Pharmacokinetic Exposure to Fexofenadine is Volume‐Dependently Reduced in Healthy Subjects Following Oral Administration With Apple Juice

Pharmacokinetic exposures to fexofenadine (FEX) are reduced by apple juice (AJ); however, the relationship between the AJ volume and the degree of AJ‐FEX interaction has not been understood. In this crossover study, 10 healthy subjects received single doses of FEX 60 mg with different volumes (150,...

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Veröffentlicht in:	Clinical and translational science 2016-08, Vol.9 (4), p.201-206
Hauptverfasser:	Luo, J, Imai, H, Ohyama, T, Hashimoto, S, Hasunuma, T, Inoue, Y, Kotegawa, T, Ohashi, K, Uemura, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Beverages Blood & organ donations Clinical trials Drug dosages Exposure Female Fexofenadine Fruit juices Healthy Volunteers Humans Laboratories Male Malus Medical research Oral administration Pharmaceuticals Pharmacokinetics Studies Terfenadine - administration & dosage Terfenadine - analogs & derivatives Terfenadine - blood Terfenadine - pharmacokinetics
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