Translational Potential of Systems-Based Models of Inflammation
A critical goal of translational research is to convert basic science to clinically relevant actions related to disease prevention, diagnosis, and eventually enable physicians to identify and evaluate treatment strategies. Integrated initiatives are identified as valuable in uncovering the mechanism...
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| Veröffentlicht in: | Clinical and translational science 2009-02, Vol.2 (1), p.85-89 |
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| container_title | Clinical and translational science |
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| creator | Foteinou, P.T. Calvano, S.E. Lowry, S.F. Androulakis, I.P. |
| description | A critical goal of translational research is to convert basic science to clinically relevant actions related to disease prevention, diagnosis, and eventually enable physicians to identify and evaluate treatment strategies. Integrated initiatives are identified as valuable in uncovering the mechanism underpinning the progression of human diseases. Tremendous opportunities have emerged in the context of systems biology that aims at the deconvolution of complex phenomena to their constituent elements and the quantification of the dynamic nteractions between these components through the development of appropriate computational and mathematical models. In this review, we discuss the potential role systems‐based translation research can have in the quest to better understand and modulate the nflammatory response. |
| doi_str_mv | 10.1111/j.1752-8062.2008.00051.x |
| format | Article |
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In this review, we discuss the potential role systems‐based translation research can have in the quest to better understand and modulate the nflammatory response.</description><subject>Bacterial infections</subject><subject>Collaboration</subject><subject>Computer applications</subject><subject>Cytokines</subject><subject>Disease</subject><subject>Fatty acids</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immune system</subject><subject>Infections</subject><subject>Inflammation</subject><subject>Inflammation - immunology</subject><subject>Mathematical models</subject><subject>modeling</subject><subject>Models, Immunological</subject><subject>Mortality</subject><subject>Pathogens</subject><subject>Physiology</subject><subject>Sepsis</subject><subject>systems biology</subject><subject>Translation</subject><subject>Translational Research, Biomedical</subject><issn>1752-8054</issn><issn>1752-8062</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkV9v0zAUxS3ExMbgK6BKSPCUYMd_IyEmVrEyqRuIFXi8cmIHUpx42Cm03x5nHRHjAXFffOX7O0fXPgjNCM5JqhfrnEheZAqLIi8wVjnGmJN8ew8dTYP7U8_ZIXoY4xpjQYXiD9BhgRmjStIjdLIKuo9OD63vtZu994PthzZ1vpld7eJgu5id6mjN7MIb6-J4f943TnfdjeYROmi0i_bx7XmMPp69Wc3fZst3i_P562VWc1GSjNWMG1OLRinNqqbmrBDMlkQSWVHWaGNFTaxstOLU6LKipCLYWG001UYWgh6jV3vf603VWVOnLYN2cB3aTocdeN3C3UnffoUv_gdwyrEsSTJ4fmsQ_PeNjQN0baytc7q3fhNBUlpyUjKZyGf_JAssmVCCJvDpX-Dab0L6xsTQMpUSBU6U2lN18DEG20xLEwxjmrCGMSgYQ4MxTbhJE7ZJ-uTPR0_C3_El4OUe-Nk6u_tvY5ivrlKT5Nle3qagt5Nch28gJJUcPl8u4NPpGVt-UAsg9Be6cL1g</recordid><startdate>200902</startdate><enddate>200902</enddate><creator>Foteinou, P.T.</creator><creator>Calvano, S.E.</creator><creator>Lowry, S.F.</creator><creator>Androulakis, I.P.</creator><general>Blackwell Publishing Inc</general><general>John Wiley & Sons, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200902</creationdate><title>Translational Potential of Systems-Based Models of Inflammation</title><author>Foteinou, P.T. ; 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| language | eng |
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| subjects | Bacterial infections Collaboration Computer applications Cytokines Disease Fatty acids Gene expression Humans Immune system Infections Inflammation Inflammation - immunology Mathematical models modeling Models, Immunological Mortality Pathogens Physiology Sepsis systems biology Translation Translational Research, Biomedical |
| title | Translational Potential of Systems-Based Models of Inflammation |
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