Hypoxic Preconditioning Protects against Ischemic Brain Injury

Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia preconditioning requires new RNA and protein synthesis. The mechanism of this hypoxia-induced tolerance correlates with the...

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Veröffentlicht in:	NeuroRx 2004, Vol.1 (1), p.26-35
Hauptverfasser:	Sharp, Frank R., Ran, Ruiqiong, Lu, Aigang, Tang, Yang, Strauss, Kenneth I., Glass, Todd, Ardizzone, Tim, Bernaudin, Myriam
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aryl Hydrocarbon Receptor Nuclear Translocator Brain - metabolism Brain - pathology Brain - physiopathology Brain Ischemia - genetics Brain Ischemia - physiopathology DNA-Binding Proteins - metabolism EPO erythropoietin Gene Expression HIF Hypoxia hypoxia-inducible factor Hypoxia-Inducible Factor 1, alpha Subunit Ischemia Ischemic Preconditioning oxygen preconditioning Rats Receptors, Aryl Hydrocarbon - metabolism Review Rodents stress proteins stroke Transcription Factors - metabolism VEGF
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