Cellular Active N-Hydroxyurea FEN1 Inhibitors Block Substrate Entry to the Active Site

The structure-specific nuclease human flap endonuclease-1 (hFEN1) plays a key role in DNA replication and repair and may be of interest as an oncology target. We present the first crystal structure of inhibitor-bound hFEN1 and show a cyclic N -hydroxyurea bound in the active site coordinated to two...

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Veröffentlicht in:	Nature chemical biology 2016-08, Vol.12 (10), p.815-821
Hauptverfasser:	Exell, Jack C., Thompson, Mark J., Finger, L. David, Shaw, Steven J., Debreczeni, Judit, Ward, Thomas A., McWhirter, Claire, Siöberg, Catrine L. B., Martinez Molina, Daniel, Mark Abbott, W., Jones, Clifford D., Nissink, J. Willem M., Durant, Stephen T., Grasby, Jane A.
Format:	Artikel
Sprache:	eng
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