A Hexasaccharide Containing Rare 2‐O‐Sulfate‐Glucuronic Acid Residues Selectively Activates Heparin Cofactor II

Glycosaminoglycan (GAG) sequences that selectively target heparin cofactor II (HCII), a key serpin present in human plasma, remain unknown. Using a computational strategy on a library of 46 656 heparan sulfate hexasaccharides we identified a rare sequence consisting of consecutive glucuronic acid 2‐...

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Veröffentlicht in:	Angewandte Chemie International Edition 2017-02, Vol.56 (9), p.2312-2317
Hauptverfasser:	Sankaranarayanan, Nehru Viji, Strebel, Tamara R., Boothello, Rio S., Sheerin, Kevin, Raghuraman, Arjun, Sallas, Florence, Mosier, Philip D., Watermeyer, Nicholas D., Oscarson, Stefan, Desai, Umesh R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Anticoagulants Antithrombin Blood plasma carbohydrates chemical biology Communication Communications Computation Computer applications Discovery tools Drug Discovery Glucuronates - chemistry Glucuronates - pharmacology glycosaminoglycans Heparan sulfate Heparin Heparin Cofactor II - agonists Heparin Cofactor II - metabolism Heparitin Sulfate - chemistry Heparitin Sulfate - pharmacology Humans in silico screening Protein Binding Residues serpins Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology Sulfates
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