Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine

Aims This study aimed to characterize the pharmacokinetics of oxycodone and its major metabolites in infants and covered the age range between extremely preterm neonates and 2‐year‐old infants. Methods Seventy‐nine infants (gestational age 23–42 weeks; postnatal age 0–650 days) received intravenous...

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Veröffentlicht in:	British journal of clinical pharmacology 2017-04, Vol.83 (4), p.791-800
Hauptverfasser:	Kokki, Merja, Heikkinen, Marja, Välitalo, Pyry, Hautajärvi, Heidi, Hokkanen, Juho, Pitkänen, Hanna, Sankilampi, Ulla, Ranta, Veli‐Pekka, Kokki, Hannu
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Analgesics, Opioid - administration & dosage Analgesics, Opioid - pharmacokinetics Child, Preschool Female Half-Life Humans Infant Infant, Extremely Premature Infant, Newborn Infant, Premature Male Morphinans - pharmacokinetics neonate oxycodone Oxycodone - administration & dosage Oxycodone - pharmacokinetics Pharmacokinetics preterm Prospective Studies Time Factors
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