Exosomes and Cardiovascular Protection
Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-cal...
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| Veröffentlicht in: | Cardiovascular drugs and therapy 2017-02, Vol.31 (1), p.77-86 |
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| container_title | Cardiovascular drugs and therapy |
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| creator | Davidson, Sean M. Takov, Kaloyan Yellon, Derek M. |
| description | Most, if not all, cells of the cardiovascular system secrete small, lipid bilayer vesicles called exosomes. Despite technical challenges in their purification and analysis, exosomes from various sources have been shown to be powerfully cardioprotective. Indeed, it is possible that much of the so-called “paracrine” benefit in cardiovascular function obtained by stem cell therapy can be replicated by the injection of exosomes produced by stem cells. However, exosomes purified from plasma appear to be just as capable of activating cardioprotective pathways. We discuss the potential roles of endogenous exosomes in the cardiovascular system, how this is perturbed in cardiovascular disease, and evaluate their potential as therapeutic agents to protect the heart. |
| doi_str_mv | 10.1007/s10557-016-6698-6 |
| format | Article |
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| subjects | Animals Cardiology Cardiovascular Diseases - metabolism Cardiovascular Diseases - pathology Cardiovascular Diseases - physiopathology Cardiovascular Diseases - therapy Cell-Derived Microparticles - metabolism Cell-Derived Microparticles - transplantation Exosomes - metabolism Exosomes - transplantation Humans Medicine Medicine & Public Health Myocardium - metabolism Myocardium - pathology Original Original Article Signal Transduction Stem Cell Transplantation - methods Treatment Outcome |
| title | Exosomes and Cardiovascular Protection |
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