JNK potentiates TNF-stimulated necrosis by increasing the production of cytotoxic reactive oxygen species

The c-Jun NH(2)-terminal kinase (JNK) has been implicated in both cell death and survival responses to different stimuli. Here we reexamine the function of JNK in tumor necrosis factor (TNF)-stimulated cell death using fibroblasts isolated from wild-type, Mkk4(-/-) Mkk7(-/-), and Jnk1(-/-) Jnk2(-/-)...

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Veröffentlicht in:	Genes & development 2004-12, Vol.18 (23), p.2905-2915
Hauptverfasser:	Ventura, Juan-Jose, Cogswell, Patricia, Flavell, Richard A, Baldwin, Jr, Albert S, Davis, Roger J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Death - physiology JNK Mitogen-Activated Protein Kinases - physiology MAP Kinase Kinase 4 Mice Mitogen-Activated Protein Kinase Kinases - physiology Reactive Oxygen Species Research Papers Tumor Necrosis Factor-alpha - physiology
Online-Zugang:	Volltext
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