Absent in Melanoma 2 proteins in SLE

Abstract Type I interferons (IFN-α/β)-inducible PYRIN and HIN domain-containing protein family includes Absent in Melanoma 2 (murine Aim2 and human AIM2), murine p202, and human PYRIN-only protein 3 (POP3). The generation of Aim2 -deficient mice indicated that the Aim2 protein is essential for infla...

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Veröffentlicht in:	Clinical immunology (Orlando, Fla.) Fla.), 2017-03, Vol.176, p.42-48
Hauptverfasser:	Choubey, Divaker, Panchanathan, Ravichandran
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism AIM2 Allergy and Immunology Animals DNA-Binding Proteins - metabolism Humans IFN-signature Inflammasome Interferon Interferon Type I - metabolism Interleukin-18 - metabolism Interleukin-1beta - metabolism Lupus Lupus Erythematosus, Systemic - metabolism Melanoma - metabolism Tumor Suppressor p53-Binding Protein 1 - metabolism
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