Perivascular cells and tissue engineering: Current applications and untapped potential
The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have bee...
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| Veröffentlicht in: | Pharmacology & therapeutics (Oxford) 2017-03, Vol.171, p.83-92 |
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| container_title | Pharmacology & therapeutics (Oxford) |
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| creator | Avolio, Elisa Alvino, Valeria V Ghorbel, Mohamed T Campagnolo, Paola |
| description | The recent development of tissue engineering provides exciting new perspectives for the replacement of failing organs and the repair of damaged tissues. Perivascular cells, including vascular smooth muscle cells, pericytes and other tissue specific populations residing around blood vessels, have been isolated from many organs and are known to participate to the in situ repair process and angiogenesis. Their potential has been harnessed for cell therapy of numerous pathologies; however, in this Review we will discuss the potential of perivascular cells in the development of tissue engineering solutions for healthcare. We will examine their application in the engineering of vascular grafts, cardiac patches and bone substitutes as well as other tissue engineering applications and we will focus on their extensive use in the vascularization of engineered constructs. Additionally, we will discuss the emerging potential of human pericytes for the development of efficient, vascularized and non-immunogenic engineered constructs. |
| doi_str_mv | 10.1016/j.pharmthera.2016.11.002 |
| format | Article |
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Madeddu</subject><subject>Biocompatible Materials - metabolism</subject><subject>Blood Vessels - cytology</subject><subject>Cell- and Tissue-Based Therapy - methods</subject><subject>Humans</subject><subject>Muscle, Smooth, Vascular - cytology</subject><subject>Myocytes, Smooth Muscle - cytology</subject><subject>Neovascularization, Physiologic - physiology</subject><subject>Pericytes - cytology</subject><subject>Tissue Engineering - methods</subject><issn>0163-7258</issn><issn>1879-016X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkVtLxDAQhYMoul7-gvTRl9akSdvUB0EWbyDog4pvYTaZ7mbppjVpF_z3ZlmvTwNnzpwZ5iMkYTRjlJXny6xfgF8NC_SQ5VHJGMsozXfIhMmqTqPytksmsfC0ygt5QA5DWFJKhaD5PjnIKylrntcT8vqE3q4h6LEFn2hs25CAM8lgQxgxQTe3DqPFzS-S6eg9uiGBvm-thsF2bmse3RA1NEnfDdFgoT0mew20AU--6hF5ubl-nt6lD4-399Orh1QLWQ4psFw2sq7LphG1MKySpuK6LrnWmiJWIIzQoCmgnJkZ1YZBWTVYcYaNNKD5Ebnc5vbjbIVGx-0eWtV7uwL_oTqw6n_H2YWad2tVcFGUtYwBZ18BvnsfMQxqZcPmDeCwG4NiUgheiCKn0Sq3Vu27EDw2P2sYVRssaql-sagNFsWYilji6OnfM38GvznwT83pkYw</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Avolio, Elisa</creator><creator>Alvino, Valeria V</creator><creator>Ghorbel, Mohamed T</creator><creator>Campagnolo, Paola</creator><general>Pergamon Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201703</creationdate><title>Perivascular cells and tissue engineering: Current applications and untapped potential</title><author>Avolio, Elisa ; Alvino, Valeria V ; Ghorbel, Mohamed T ; Campagnolo, Paola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486t-a128f8996ff494d178d73c963ccc0ee7a4d4cac0ae8bdb0cd1a67fe731ef8dac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Associate editor: P. 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| fulltext | fulltext |
| identifier | ISSN: 0163-7258 |
| ispartof | Pharmacology & therapeutics (Oxford), 2017-03, Vol.171, p.83-92 |
| issn | 0163-7258 1879-016X |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Animals Associate editor: P. Madeddu Biocompatible Materials - metabolism Blood Vessels - cytology Cell- and Tissue-Based Therapy - methods Humans Muscle, Smooth, Vascular - cytology Myocytes, Smooth Muscle - cytology Neovascularization, Physiologic - physiology Pericytes - cytology Tissue Engineering - methods |
| title | Perivascular cells and tissue engineering: Current applications and untapped potential |
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